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Visar resultat 6 - 10 av 195 avhandlingar som matchar ovanstående sökkriterier.
6. Intracellular unbound drug concentrations : Methodology and application for understanding cellular drug exposure
Sammanfattning : Most known drug targets and metabolizing enzymes are located inside cells. Interactions with these proteins are determined by intracellular unbound drug concentrations. Assessing intracellular drug exposure is technically challenging, but essential for predicting pharmacokinetic, pharmacological, and toxicological profiles of new drugs. LÄS MER
7. Towards a Multi-OS Architecture for Consistent User Interface Experience
Sammanfattning : Vehicles have greatly changed over the last decades. Originally, they were used as a means of transportation, and their drivers were solely engaged in the driving task. In modern cars the user, i.e. LÄS MER
8. Numerical simulations of long spark gaps – lightning attachment and its application
Sammanfattning : The Licenciate Thesis presented here is a research work on numerical simulations of two different electrical phenomena: Long gap discharges under switching impulses and the lightning attachment process of positive upward leaders. The development of a positive upward leader and the process of progress of a discharge in long gaps are composed of two intertwined physical phenomena, namely the leader channel and the corona zone. LÄS MER
9. Integrative approaches in ecotoxicological testing: Implications for biomarker development and application
Sammanfattning : Ecotoxicology aims to understand toxic effects of chemicals in the environment. Effects can be observed at different levels of the biological organization, from molecular to ecosystem level. LÄS MER
10. Standardization and application of quantitative PCR methods in patients with hematological malignancies
Sammanfattning : Using modem combination chemotherapy regimens, it has been possible to increase the rate of complete remission (CR) in acute lymphoblastic (ALL) and acute myeloid leukemia (AML). The major reason for treatment failure in acute leukemia (AL) is the resistance of leukemic blasts to chemotherapeutic agents, which is accompanied by an inability of the immune system to eradicate residual leukemic cells surviving initial treatment. LÄS MER