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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. The quality control of MHC class I antigen presentation

    Författare :Kajsa M Paulsson; Antigen presentation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chaperone; assembly; COPI; antigenic peptide; TAP; MHC; tapasin; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells. The peptides are generated by proteasomes in the cytosol, then translocated across the membrane of the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). LÄS MER

  3. 2. Multiple twists in the molecular tales of YopD and LcrH in type III secretion by Yersinia pseudotuberculosis

    Författare :Petra J Edqvist; Matthew Francis; Olaf Schneewind; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yersinia pseudotuberculosis; T3SS; YopD; translocation process; LcrH; class II chaperone; substrate secretion pathway specificity; Molecular biology; Molekylärbiologi;

    Sammanfattning : The type III secretion system (T3SS) is a highly conserved secretion system among Gram negative bacteria that translocates anti-host proteins directly into the infected cells to overcome the host immune system and establish a bacterial infection. Yersinia pseudotuberculosis is one of three pathogenic Yersinia spp. LÄS MER

  4. 3. YopD translocator function in Yersinia pseudotuberculosis type III secretion

    Författare :Tiago R. D. Costa; Matthew S. Francis; William D. Picking; Umeå universitet; []
    Nyckelord :Y. pseudotuberculosis; T3SS; translocon; YopD; coiled-coil; effector delivery; regulation; virulence; mikrobiologi; Microbiology;

    Sammanfattning : Type III secretion systems (T3SS) are a common feature of Gram-negative bacteria, allowing them to inject anti-host effectors into the interior of infected eukaryotic cells. By this mechanism, these virulence factors help the bacteria to modulate eukaryotic cell function in its favor and subvert host innate immunity. LÄS MER

  5. 4. Critical illness myopathy : mechanisms and pharmacological interventions

    Författare :Hazem Akkad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human body typically contains over 600 skeletal muscles that make up about 40% of total body weight. These muscles work together to perform functions such as locomotion, breathing, mastication, heat regulation and speech. LÄS MER

  7. 5. To degrade or not to degrade : protein handling by the proteasome

    Författare :Christian Heinen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The proteasome, a large multi-subunit protease that degrades proteins, must be able to distinguish between substrates deemed for destruction and accessory proteins that should be spared. The shuttle factor Rad23 operates in close proximity to the proteasome in order to deliver proteins for their degradation. LÄS MER