Sökning: "cell-penetrating peptide"

Visar resultat 21 - 25 av 67 avhandlingar innehållade orden cell-penetrating peptide.

  1. 21. Cell-Penetrating Penetratin Peptides - Mechanistic Studies on Uptake Pathways and DNA Delivery Efficiency

    Författare :Helene Åmand; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plasma membrane vesicle; Lysine; Stimulated endocytosis; Gene delivery; Cell surface affinity; Penetratin; Cell-penetrating peptide; Cysteine; Uptake; Arginine;

    Sammanfattning : Delivery of gene-targeted drugs is limited by the inherently poor capacity of nucleic acids to overcome the membrane barrier of the cell, and development of vectors that can promote uptake is therefore crucial. Cell penetrating peptides (CPPs) have emerged as promising vector candidates due to their ability to deliver a wide range of macromolecular cargos into cells. LÄS MER

  3. 22. Cell-penetrating peptides; chemical modification, mechanism of uptake and formulation development

    Författare :Kariem Ezzat; Ülo Langel; Steven Dowdy; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell penetrating peptides; gene therapy; scavenger receptors; pharmaceutical formulation; solid dispersion; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Gene therapy holds the promise of revolutionizing the way we treat diseases. By using recombinant DNA and oligonucleotides (ONs), gene functions can be restored, altered or silenced according to the therapeutic need. LÄS MER

  4. 23. Naturally derived cell-penetrating peptides and applications in gene regulation : A study on internalization mechanisms and endosomal escape

    Författare :Pontus Lundberg; Ülo Langel; Bernard Lebleu; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptide; oligonucleotide; endocytosis; gene regulation; Neurochemistry; Neurokemi;

    Sammanfattning : Cell-penetrating peptides are a class of peptides which have achieved a lot of recognition due to their vector abilities. Since their discovery over a decade ago, there has been an uncertainty concerning the mechanism by which they are internalized into the cells. LÄS MER

  5. 24. Biophysical studies of cell-penetrating peptides and of the RNR inhibitor Sml1

    Författare :Elsa Bárány-Wallje; Astrid Gräslund; Joachim Seelig; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; transportan; bicelles; Sml1; Biophysics; Biofysik; Biophysics; biofysik;

    Sammanfattning : Several short peptides, so called cell-penetrating peptides, have the capability to transport large hydrophilic cargos through the cell membrane. The objective is to use these peptides as drug carriers and thereby enhance the uptake of drugs into cells.Three different cell-penetrating peptides are characterized in this thesis. LÄS MER

  7. 25. Intracellular Uptake and Membrane Binding of Cell-penetrating Peptides: The Influence of Arginines, Tryptophans and Proteoglycans

    Författare :Hanna Rydberg; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; membrane-binding; cellular uptake; proteoglycans; tryptophan; arginine-rich peptide;

    Sammanfattning : One of the major limitations in the realization of functional gene therapy is efficient intracellular transport of the therapeutic macromolecules. Amongst several different techniques, cell-penetrating peptides (CPPs) have emerged as promising candidates for this purpose. LÄS MER