Sökning: "cell-penetrating peptide"

Visar resultat 6 - 10 av 67 avhandlingar innehållade orden cell-penetrating peptide.

  1. 6. PepFect14, a Versatile Cell-Penetrating Peptide

    Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Författare :Maxime Gestin; Ülo Langel; Anna-Lena Ström; Angelita Rebollo; [2020]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-Penetrating Peptides; PepFect14; transfection; signaling mechanisms; intracellular targeting; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Cell-penetrating peptides have been discovered almost three decades ago and there are, nowadays, thousands of available sequences. They offer multiple applications in the field of drug delivery as they are able to carry therapeutic macromolecules across the plasma membrane. LÄS MER

  2. 7. Cell-penetrating peptides and oligonucleotides Design, uptake and therapeutic applications

    Detta är en avhandling från Stockholm : Department of Neurochemistry, Stockholm University

    Författare :Andrés Muñoz-Alarcón; Ülo Langel; Sandrine Sagan; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; oligonucleotides; scavenger receptors; telomerase; gene therapy; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Regulation of biological processes through the use of genetic elements is a central part of biological research and also holds great promise for future therapeutic applications. Oligonucleotides comprise a class of versatile biomolecules capable of modulating gene regulation. LÄS MER

  3. 8. Cell-penetrating peptides and bioactive cargoes Strategies and mechanisms

    Detta är en avhandling från Stockholm : Institutionen för neurokemi

    Författare :Kalle Kilk; Ülo Langel; Michael J. Gait; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; delivery; Peptide nucleic acid; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Sammanfattning : The cell membrane is an impermeable barrier for most macromolecules. Recently discovered cell-penetrating peptides (CPPs) have gained lot of attention because they can cross the membrane, and even more, carry cargoes with them. How CPPs enter cells is still not clear, while the delivery of different cargoes has been convincingly shown. LÄS MER

  4. 9. Oligonucleotide Complexes with Cell-Penetrating Peptides Structure, Binding, Translocation and Flux in Lipid Membranes

    Detta är en avhandling från Stockholm : Department of Neurochemistry, Stockholm University

    Författare :Luis Daniel Ferreira Vasconcelos; Ülo Langel; Tore Bengtsson; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; Large unilamellar vesicle; Membrane perturbation; Endosomal escape; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The ability of cell-penetrating peptides to cross plasma membranes has been explored for various applications, including the delivery of bioactive molecules to inhibit disease-causing cellular processes. The uptake mechanisms by which cell-penetrating peptides enter cells depend on the conditions, such as the cell line the concentration and the temperature. LÄS MER

  5. 10. Cell-penetrating peptides in protein mimicry and oligonucleotide delivery Applications and mechanisms

    Detta är en avhandling från Stockholm : Institutionen för neurokemi

    Författare :Henrik Johansson; Ülo Langel; Michael Gait; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptide; oligonucleotide; cell-penetrating peptide; PNA; splicing; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : The plasma membrane functions as a barrier, restricting entry of hydrophilic pharmaceutical agents. Cell-penetrating peptides (CPPs) are capable of transporting bioactive cargos into the cell and have consequently been extensively investigated for their mechanism of entry and capability to deliver various cargos spanning from peptides to plasmids. LÄS MER