Sökning: "beta2"

Visar resultat 16 - 20 av 33 avhandlingar innehållade ordet beta2.

  1. 16. SAR Studies of Capsazepinod Bronchodilators. The A-ring and the Coupling region

    Författare :Maria Dalence; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; COPD; Asthma; Capsazepine; Bronchodilators; Organic chemistry; SAR studies; Organisk kemi;

    Sammanfattning : Bronchoconstriction is a hallmark in respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Current therapies use bronchodilating agents in order to control the exacerbations produced by limited airflow and improve the quality of life of patients suffering from these diseases. LÄS MER

  3. 17. SAR studies of Capsazepinoid Bronchodilators The B-ring and the C-region

    Författare :Magnus Berglund; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; bronchodilator; Capsazepine; structure activity relationship;

    Sammanfattning : Capsazepine and similar compounds, capsazepinoids, were shown to be general inhibitors of agonist (leukotriene D4, histamine, acetylcholine, prostaglandin D2) evoked constriction of human small airway preparations. The mechanism of action remains to be elucidated, but established bronchodilator principles, e.g. LÄS MER

  4. 18. Polycystic ovary syndrome : a study of adipocyte lipolysis in relation to endocrine and metabolic status

    Författare :Ingvar Ek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adipocyte; beta-adrenoceptors; FFA; hyperandrogenism; HSL; insulin resistance; lipolysis; PCOS; PKA;

    Sammanfattning : The aim of the present thesis was to obtain insight into possible regulatory effects of androgens on the regulation of lipolysis in subcutaneous as well as visceral adipose tissue in women with the polycystic ovary syndrome (PCOS). In non-obese women with PCOS, adrenergic lipolysis was investigated in both subcutaneous abdominal and visceral adipose tissue and several, novel disturbances were found. LÄS MER

  5. 19. Functional and structural characterization of integrins and their ligands ICAM-2, vitronectin and fibronectin in leukocytes

    Författare :Rosalba Salcedo Amaya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Leukocytes; Adhesion molecules; Integrins; ICAM-2; Vitronectin; Fibronectin.;

    Sammanfattning : Transient adhesion of leukocytes to cells and extracellular matrices is a crucial process in leukocyte physiology. Cell surface adhesion molecules such as integrins and members of the immunoglobulin (Ig) superfamily are involved. LÄS MER

  7. 20. Characterization and expression of subtypes of nicotinic receptors in brain and adrenal medulla : with focus on development, Alzheimer's disease and transgenic animal models

    Författare :Malahat Mousavi Tasouji; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cholinergic nicotinic receptors (nAChRs) seem to play an important role in numerous important physiological processes in brain as well as peripheral tissues of man. In first trimester human brain mRNA levels for the alpha3, alpha4, alpha5, alpha7, beta2, beta3, and beta4 nAChR subunits and binding sites were detected at 5 weeks of gestation. LÄS MER