Sökning: "beta2"

Visar resultat 11 - 15 av 33 avhandlingar innehållade ordet beta2.

  1. 11. Mechanisms for leukocyte-mediated adjustment of endothelial barrier function

    Författare :Narinder Gautam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Inflammation; leukocyte extravasation; endothelial cells; vascular permeability; plasma leakage integrin signaling; heparin binding protein; contact phase; bradykinin.;

    Sammanfattning : Extravasation of polymorphonuclear leukocytes (PMN) and associated plasma exsudation are key events in the inflammatory process. The mechanism by which activated PMN may induce increased vascular permeability for macromolecules is not fully understood but crucially dependent on an intact leukocytic beta2 integrin (CD11/CD18) adhesion receptor function. LÄS MER

  3. 12. Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol lowering drugs in Alzheimer's disease

    Författare :Jin Xiu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nicotinic acetylcholine receptor; Alzheimer s disease; glia cells; Abeta; cholesterol; cholesterollowering drugs;

    Sammanfattning : Nicotinic acetylcholine receptors (nAChRs) are involved in the regulation of many processes including synapses regeneration, neurotransmission and neuroprotection in the central nervous system (CNS). There is increasing evidence for the disturbances in nAChRs in Alzheimer's disease (AD). LÄS MER

  4. 13. Role of adhesion molecules and chemokines in TNF-alpha-induced leukocyte recruitment

    Författare :Xiao Wei Zhang; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; intravital microscopy; microcirculation; inflammation; adhesion; leukocyte; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : Migration of leukocytes from the circulating blood into the extravascular tissue is a key component in inflammatory reactions. Leukocyte extravasation (rolling-activation-adhesion-transmigration) is strictly coordinated by adhesion molecules and chemokines expressed on cell surfaces and in tissues. LÄS MER

  5. 14. Cardiac electrophysiologic effects of mental stress

    Författare :Per Insulander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Mental stress may trigger serious arrhythmias. Mental stress tests cause significant increases in heart rate, blood pressure and cardiac output. When beta-adrenergic inhibition is considered for secondary antiarrhythmic prophylaxis beta1 selective agents are often preferred because of less adverse reactions. LÄS MER

  7. 15. Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation

    Författare :Katalin Dobra; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malignant mesothelioma; differentiation; syndecan; nuclear transport; PG profile.;

    Sammanfattning : Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they possess a biphasic growth potential and can be stimulated by serum growth factors to differentiate into stable epithelial or fibrous phenotypes. LÄS MER