Sökning: "aromatase"

Visar resultat 6 - 10 av 36 avhandlingar innehållade ordet aromatase.

  1. 6. Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation : Special Focus on Vitamin D and Sex Hormones

    Författare :Johan Lundqvist; Kjell Wikvall; Maria Norlin; Magnus Ingelman-Sundberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenal steroidogenesis; CYP7B1; vitamin D; calcitriol; enzymatic regulation; transcriptional regulation; CYP21A2; aromatase; sex hormone; estrogen; androgen; nuclear receptor; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : Enzyme-catalyzed reactions are important to regulate steroidogenesis and nuclear receptor activation. The present investigation examines the role of steroid metabolism catalyzed by CYP7B1 for regulation of hormone receptor activation and the effects of vitamin D on enzymatic regulation of steroidogenesis. LÄS MER

  3. 7. Studies of hyperandrogenicity and the metabolic syndrome in premenopausal women

    Författare :Fariba Baghaei; Göteborgs universitet; []
    Nyckelord :androgens; SHBG; HPA axis; abdominal obesity; insulin; HDL; metabolic syndrome; ovarian volume; PCOS; polymorphism; genetics; androgen receptor; estrogen receptor; aromatase;

    Sammanfattning : An androgenic sex hormone profile appears to be a typical feature of the metabolic syndrome (MetS) and a powerful risk factor for the development of type 2 diabetes in women. The causes of relative hyperandrogenicity (HA) are not clearly defined. LÄS MER

  4. 8. Brain Aromatase in the guppy, Poecilia reticulata : Distribution, control and role in behaviour

    Författare :Stefan Hallgren; Håkan Olsén; Bertil Borg; Julie Bakker; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Oestrogen production; behaviour; anatomy; endocrinology; bio markers; endocrine disruption; Organism biology; Organismbiologi; funktionell morfologi; Functional Zoomorphology; Biology;

    Sammanfattning : Oestrogens are produced by aromatisation of androgens by the aromatase enzyme. In the vertebrate brain this synthesis has vital functions in nerve protection, cell proliferation and nerve development during injury respectively brain development. LÄS MER

  5. 9. Hormonal Regulation of Vaginal Mucosa

    Författare :Theodora Kunovac Kallak; Anneli Staverus-Evers; Inger Sundström Poromaa; Philippa Saunders; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aromatase inhibitors; vaginal atrophy; estrogen; proliferation; steroid hormone receptors; cell differentiation; cell adhesion; aquaporin 3;

    Sammanfattning : Vaginal atrophy symptoms such as dryness, irritation, and itching, are common after menopause. Vaginal estrogen therapy is the most effective treatment but not appropriate for all women. LÄS MER

  7. 10. LXR and aromatase knock-out mice : animal models providing insight into human diseases

    Författare :Hyun-Jin Kim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In our characterization of mouse strains carrying mutations in nuclear receptor and aromatase genes we have found phenotypes which resemble four human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome (SS), amyotrophic lateral sclerosis (ALS), and exocrine pancreatic insufficiency. The work in this thesis was designed to understand the roles of LXRalpha, LXRbeta and aromatase in development of these diseases and to investigate whether these animal models help us (1) to understand the etiology of the corresponding human diseases and (2) to develop new therapeutic approaches for the treatment of these diseases. LÄS MER