Sökning: "androgen"

Visar resultat 1 - 5 av 175 avhandlingar innehållade ordet androgen.

  1. 1. Functional characterisation of the CAG polymorphism in the androgen receptor- in vitro and in vivo

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Hannah Nenonen; Lunds universitet.; Lund University.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; androgen receptor; polymorphism; CAG polymorphism; androgen receptor activity; infertility; prostate cancer; androgen receptor function;

    Sammanfattning : The androgen receptor (AR) is the mediator of androgen actions. In the AR coding region there is a polymorphic CAG repeat encoding a stretch of the amino acid glutamine (Q). The repeat length modulates receptor activity and is normally distributed between 10-30 CAG with a median length of 22 repeats in white men. LÄS MER

  2. 2. Androgen receptors and endocrine disrupting substances

    Detta är en avhandling från Örebro : Örebro universitet

    Författare :Anders Larsson; Örebro universitet.; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Androgen receptor; Brominated flame retardant; TBECH; Endocrine disruptor; NATURAL SCIENCES Biology; NATURVETENSKAP Biologi; NATURAL SCIENCES; NATURVETENSKAP; Biology; Biologi;

    Sammanfattning : Throughout the animal kingdom, organisms are dependent on substances such as steroid hormones to help them maintain internal balances. Examples of important tasks that are under regulation of steroid hormones are somatic and gonadal development, sexual performance and behavior (both social and sexual) as well as sex differentiation. LÄS MER

  3. 3. Androgen controlled regulatory systems in prostate cancer potential new therapeutic targets and prognostic markers

    Detta är en avhandling från Umeå : Medicinsk biovetenskap

    Författare :Peter Hammarsten; Umeå universitet.; [2008]
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; prostate cancer; angiogenesis; human biopsy; androgen ablation; castration; prognostic marker; prognostic factor; growth control; VEGF; vascular endothelial growth factor; EGFR; epidermal growth factor receptor; pEGFR; phosphorylated EGFR; phosphorylated epidermal growth factor receptor; VETERINARY MEDICINE Pathology; VETERINÄRMEDICIN Patologi;

    Sammanfattning : BACKGROUND: Prostate cancer is by far the most common cancer among Swedish men. Some patients have an aggressive lethal disease, but the majority of affected men have long expected survival. Unfortunately, the diagnostic tools available are insufficient in predicting disease aggressiveness. Novel prognostic markers are therefore urgently needed. LÄS MER

  4. 4. Mechanisms behind growth of castration-resistant prostate cancer bone metastases

    Detta är en avhandling från Umeå : Umeå University

    Författare :Emma Jernberg; Umeå universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration-resistance; bone metastases; androgen receptor; intratumoral steroidogenesis; androgen receptor splice variants; androgen receptor amplification; patologi; Pathology;

    Sammanfattning : Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). LÄS MER

  5. 5. Androgen-Independent Prostate Cancer - studies on angiogenesis and ADAMTS1

    Detta är en avhandling från Umeå : Umeå University

    Författare :Helene Gustavsson; Göteborgs universitet.; Gothenburg University.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Androgen-independent; Castration resistant; Hormone refractory; Angiogenesis; Microvessel density; ADAMTS1; LNCaP; VEGF; TSP1;

    Sammanfattning : Androgen deprivation therapy (ADT) is the standard treatment for advanced prostate cancer since prostate tumors initially are dependent on androgens for growth. However, most tumors will eventually relapse and grow in a highly aggressive and androgen-independent (AI) manner. LÄS MER