Sökning: "bio markers"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden bio markers.

1. 1. Brain Aromatase in the guppy, Poecilia reticulata : Distribution, control and role in behaviour

   Författare :Stefan Hallgren; Håkan Olsén; Bertil Borg; Julie Bakker; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Oestrogen production; behaviour; anatomy; endocrinology; bio markers; endocrine disruption; Organism biology; Organismbiologi; funktionell morfologi; Functional Zoomorphology; Biology;

   Sammanfattning : Oestrogens are produced by aromatisation of androgens by the aromatase enzyme. In the vertebrate brain this synthesis has vital functions in nerve protection, cell proliferation and nerve development during injury respectively brain development. LÄS MER

3. 2. Synthesis of nanostructured and hierarchical materials for bio-applications

   Författare :Fei Ye; Mamoun Muhammed; Andreas Fisher; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fe3O4; mSiO2; core-shell; MRI; multifunctional; PNIPAAm; LCST; gold; nanorod; nitric acid; AR; MDDC; biocompatibility; immunomodulation; Materials chemistry; Materialkemi;

   Sammanfattning : In recent years, nanostructured materials incorporated with inorganic particles and polymers have attracted attention for simultaneous multifunctional biomedical applications. This thesis summarized three works, which are preparation of mesoporous silica coated superparamagnetic iron oxide (Fe3O4@mSiO2) nanoparticles (NPs) as magnetic resonance imaging T2 contrast agents, polymer grafted Fe3O4@mSiO2 NPs response to temperature change, synthesis and biocompatibility evaluation of high aspect ratio (AR) gold nanorods. LÄS MER

4. 3. Neuroproteomic profiling of human body fluids

   Författare :Anna Häggmark; Peter Nilsson; Jochen M. Schwenk; Katrin Marcus; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioteknologi; Biotechnology;

   Sammanfattning : This thesis provides results from affinity based studies where human body fluids were profiled to find markers for neurological diseases. Both proteins and autoantibodies were analysed using microarray technologies that can profile hundreds of analytes and hundreds of samples in parallel using small sample volumes. LÄS MER

5. 4. Computational and experimental approaches to regulatory genetic variation

   Författare :Malin Andersen; Jacob Odeberg; John Peden; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Molecular biology; Genetics; single nucleotide polymprhism SNP ; regulatory SNP; transcription factor binding site; phylogenetic footprinting; allelic imbalance; EMSA; CD36; cardiovascular disease.; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

   Sammanfattning : Genetic variation is a strong risk factor for many human diseases, including diabetes, cancer, cardiovascular disease, depression, autoimmunity and asthma. Most of the disease genes identified so far alter the amino acid sequences of encoded proteins. LÄS MER

7. 5. Antibody based plasma protein profiling

   Författare :Ulrika Qundos; Jochen M. Schwenk; Peter Nilsson; Mathias Uhlén; Ulrike Korf; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein profiling; plasma; antibody; affinity proteomics; biomark- ers; multiplex; assay development;

   Sammanfattning : This thesis is about protein profiling in serum and plasma using antibody suspension bead arrays for the analysis of biobanked samples and in the context of prostate cancer biomarker discovery. The influence of sample preparation methods on antibody based protein profiles were investigated (Papers I-III) and a prostate cancer candidate biomarker identified and verified (Papers III-V). LÄS MER