Sökning: "aromatase inhibitors"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden aromatase inhibitors.

  1. 1. Hormonal Regulation of Vaginal Mucosa

    Författare :Theodora Kunovac Kallak; Anneli Staverus-Evers; Inger Sundström Poromaa; Philippa Saunders; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aromatase inhibitors; vaginal atrophy; estrogen; proliferation; steroid hormone receptors; cell differentiation; cell adhesion; aquaporin 3;

    Sammanfattning : Vaginal atrophy symptoms such as dryness, irritation, and itching, are common after menopause. Vaginal estrogen therapy is the most effective treatment but not appropriate for all women. LÄS MER

  3. 2. Azoles and Contaminants in Treated Effluents Interact with CYP1 and CYP19 in Fish

    Författare :Kristina Beijer; Ingvar Brandt; Björn Brunström; Henner Hollert; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Azole; fungicide; chemical; CYP1A; CYP19; EROD; aromatase; effluent; STP; wastewater; fish; stickleback; rainbow trout; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : Numerous contaminants are present in mixtures in the aquatic environment. Among these are the azoles, a group of chemicals that includes both pharmaceuticals and pesticides. Azole fungicides are designed to inhibit lanosterol 14-demethylase (cytochrome P450 (CYP) 51), while other azoles are intended to inhibit aromatase (CYP19), i.e. LÄS MER

  4. 3. Targeted therapeutic strategies for prostate cancer treatment using novel lipid kinase inhibitors in combination with current drugs

    Författare :Julius Semenas; Jenny L. Persson; Anna Berghard; Maria Fällman; Thomas Grundström; Lukas Kenner; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; bone metastasis; castration-resistant; treatment; precision therapy; PIP5K1A; steroid hormone receptors; cancer stem cells; Oncology; onkologi;

    Sammanfattning : Prostate cancer (PCa) is one of the most common cancer types and the fifth cancer-related cause of death among Western world men.  The sex steroid hormone, androgen and androgen receptor (AR) play important roles in PCa progression. LÄS MER

  5. 4. Feedback control of reproduction in Atlantic salmon, Salmo salar, male parr

    Författare :Efthimia Antonopoulou; Sylvie Dufour; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; zoologi; Zoology;

    Sammanfattning : In fish, as in other vertebrates, the gonads are stimulated by two pituitary gonadotropic hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH). LH and FSH secretion are regulated by the gonadal steroids acting either directly on the pituitary or indirectly via the hypothalamus. LÄS MER

  7. 5. Integration of Tumor and Host Factors – Implications for Breast Cancer Prognosis

    Författare :Maria Simonsson; Tumörmikromiljö; []
    Nyckelord :Breast Cancer; Prognosis and survival; CYP1A2; CYP2C8; Coffee Consumption; Alcohol Consumption; Cyclooxygenase-2 COX-2 ;

    Sammanfattning : Breast cancer is the most common cancer among women worldwide, although the mortality rates have decreased in the last decades. Breast cancer is a heterogeneous disease, and treatment resistance is a significant clinical problem in spite of the overall high survival rates. LÄS MER