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Visar resultat 11 - 14 av 14 avhandlingar som matchar ovanstående sökkriterier.

  1. 11. Endogenous and treatment-induced neuroplasticity in mouse models of Parkinson's disease

    Författare :Francesco Bez; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Parkinson´s disease (PD) is an age-related neurodegenerative disorder characterized by a loss of nigral dopamine (DA) neurons that project their axons to the striatum. Striatal DA depletion causes the typical motor symptoms of PD. LÄS MER

  3. 12. On retinoid receptors, Nurr1 and related transcription factors in the CNS

    Författare :Rolf H Zetterström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nurr1; NGFI-B; Nor1; RAR; RXR; CRBP; CRABP; substantia nigra; basal ganglia; dopamine; orphan receptor; vitamin A; retinoic acid; transcription factor;

    Sammanfattning : It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects through transcription factors known as the retinoic acid receptors (RARam -ß and -y) and retinoid X receptors (RXRa, -ß and -y). LÄS MER

  4. 13. On Parkinson's disease and schizophrenia : case control studies, cellular localization and modelling of candidate genes

    Författare :Andrea Carmine; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Genetic; association; dopamine; Parkinson s disease; schizophrenia; retinoid; aldehyde; toxicity;

    Sammanfattning : The causes of many major neurodegenerative, neurodevelopmental and psychiatric diseases are unknown. This thesis has aimed at applying knowledge about the dopamine (DA) neuron system and other key systems to clinical material (DNA and post mortem brain tissue) collected from patients with Parkinson s disease (PD), schizophrenia (SZ) and controls, in order to decipher genetic risk factors. LÄS MER

  5. 14. Modeling disturbances of cholinergic systems : possible relevance for schizophrenia

    Författare :Anna Mattsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cholinergic; nucleus basalis; 192 IgG-saporin; schizophrenia; locomotor activity; dopamine; microdialysis; memory; MRI;

    Sammanfattning : Schizophrenia is a severe, chronic mental disorder. The etiology remains unknown but alterations in cholinergic neurotransmission is one, among other, disturbances in the brain that have been implicated in schizophrenia. LÄS MER