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Visar resultat 6 - 10 av 14 avhandlingar som matchar ovanstående sökkriterier.

  1. 6. PET studies on the mechanisms of action of antidepressant and antipsychotic drugs

    Författare :Kai-Chun Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Positron emission tomography (PET) is a non-invasive molecular imaging technique suitable for examination of neurochemical biomarkers in the living brain. Among these applications, PET studies are used to facilitate the development of novel psychotropic drugs. LÄS MER

  3. 7. Assessment of dopamine and serotonin release in the non-human primate brain using PET

    Författare :Sjoerd J. Finnema; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The molecular imaging technique positron emission tomography (PET) allows for non-invasive examination of biochemical markers in the living brain. For over three decades PET studies have provided important insight into the relationship of monoaminergic neurotransmitter systems to brain functioning and psychiatric disorders. LÄS MER

  4. 8. Neuroprotective Effect of Genistein : Studies in Rat Models of Parkinson’s and Alzheimer’s Disease

    Författare :Maryam Bagheri; Simin Mohseni; David Engblom; Jan Marcusson; Mark J. West; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative disorders that mainly affect the elderly population. It is believed that oxidative stress is involved in development of both these diseases and that estrogen deficiency is a risk factor for development of AD. LÄS MER

  5. 9. On the mechanisms and physiological function of somatodendritic dopamine release in substantia nigra

    Författare :Filip Bergquist; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Calcium channels; dopamine release; microdialysis; rotarod; SNARE; striatum; substantia nigra;

    Sammanfattning : Somatodendritic release of neurotransmitters is a neuronal function that is poorly understood in comparison with the more abundant terminal release. This study aimed at characterising somatodendritic dopamine release in substantia nigra in terms of release mechanisms and possible physiological function in motor control. LÄS MER

  7. 10. Neurotoxicity of methylmercury : analysis of molecular mechanisms and behavioral alterations

    Författare :Elisabetta Daré; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Apoptosis; oxidative stress; neurons; glia; rats; dopamine; locomotion; learning and memory; environmental pollutants;

    Sammanfattning : MethyImercury (MeHg) is a global pollutant that is toxic for the nervous system, especially during development. Contaminated fish is the main route of human exposure. Recent studies have indicated that neurological alterations in humans may occur even after exposure to fairly low levels of MeHg. LÄS MER