Sökning: "192 IgG-saporin"

Hittade 2 avhandlingar innehållade orden 192 IgG-saporin.

  1. 1. Modeling disturbances of cholinergic systems : possible relevance for schizophrenia

    Författare :Anna Mattsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cholinergic; nucleus basalis; 192 IgG-saporin; schizophrenia; locomotor activity; dopamine; microdialysis; memory; MRI;

    Sammanfattning : Schizophrenia is a severe, chronic mental disorder. The etiology remains unknown but alterations in cholinergic neurotransmission is one, among other, disturbances in the brain that have been implicated in schizophrenia. LÄS MER

  3. 2. Anatomical, neurochemical and behavioural consequences of immunotoxin lesions of the basal forebrain cholinergic system

    Författare :Giampiero Leanza; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural transplantation; reinnervation; axon growth; functional sparing; memory; learning; cortex; hippocampus; immunolesion; acetylcholine; basal forebrain; rat; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; Physiology; Fysiologi;

    Sammanfattning : The cholinergic hypothesis of geriatric memory dysfunction suggests that the learning and memory deficits representing the cardinal symptoms of dementia in the aged and in patients suffering from Alzheimer's disease may be attributable to a decline in the function of the cholinergic projection systems of the basal forebrain. Although many studies have addressed the issue of a causal relationship between cholinergic hypofunction and cognitive disturbance, analyses of the functional role of the basal forebrain cholinergic neuronal systems in the brain have so far been hampered by the lack of an efficient and specific cholinergic neurotoxin. LÄS MER