Sökning: "amino"

Visar resultat 31 - 35 av 1705 avhandlingar innehållade ordet amino.

1. 31. Metabolic impact of certain dietary proteins and/or amino acids - Glycaemic and hormonal responses to carbohydrate meals in healthy subject

   Författare :Ulrika Gunnerud; Avdelningen för livsmedel och läkemedel; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amino acids; dietary protein; glycaemic regulation; insulin; incretins;

   Sammanfattning : Re-occurring hyperglycaemic episodes promote subclinical low-grade inflammation and CVD in type 2 diabetes, emphasising the therapeutic role of tight blood glucose regulation. A tight blood glucose regulation is probably beneficial also in healthy subjects and mild elevations in postprandial glycaemia and triglycerides are associated with impaired flow-mediated dilation and increased markers of oxidative stress in young healthy subjects. LÄS MER

3. 32. Rate and Accuracy of Bacterial Protein Synthesis with Natural and Unnatural Amino Acids

   Författare :Ka-Weng Ieong; Måns Ehrenberg; Simpson Joseph; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; protein synthesis; translation; efficiency-accuracy trade-off; kinetics; unnatural amino acids; Molecular Biology; Molekylärbiologi;

   Sammanfattning : This thesis addresses different questions regarding the rate, efficiency, and accuracy of peptide bond formation with natural as well as unnatural amino acids: Which step is rate-limiting during peptide bond formation? How does the accuracy vary with different transfer RNAs (tRNAs) and codons and how is it relevant to the living cells? Does proofreading selection of codon reading occur in a single- or multi-step manner as theoretically suggested? How does the E. coli translation system discriminate unnatural amino acids? Based on that, how to improve the incorporation efficiencies of unnatural amino acids?Based on the study on pH dependence of peptide bond formation, we show that the rate of the chemistry of peptidyl transfer to aminoacyl-tRNA (AA-tRNA) Gly-tRNAGly or Pro-tRNAPro limits the rate of peptide bond formation at physiological pH 7. LÄS MER

4. 33. Characterization of a new amino acid transport system in human epidermal Langerhans cells

   Författare :Niels Bendsöe; Lund Dermatologi och venereologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amino acid transport; energy charge; epidermis; glycolysis; lactate; Langerhans cells; L-dopa; mitochondria; omeprazole; Dermatology; venereology; Dermatologi; venereologi;

   Sammanfattning : Based on the discovery of a new amino acid transport system in Langerhans cells (LC), various aspects concerning the L-dopa uptake mechanism into human epidermal LC and the energy metabolism of epidermis have been examined and subsequently characterised. The system lacks any characteristics of other described amino acid transport systems in other cell types. LÄS MER

5. 34. Expanding the Amino Acid Alphabet by Design : Enhanced and Controlled Catalytic Activity in Folded Polypeptide Catalysts

   Författare :N. Johan V. Lindgren; Lars Baltzer; Harri Lönnberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemistry; Kemi; Organic Chemistry; organisk kemi;

   Sammanfattning : This thesis addresses structure and reactivity of polypeptide catalysts in reactions that mimic the hydrolysis of RNA and DNA. A designed helix-loop-helix motif was used as a scaffold where the amino acid residues were systematically varied. LÄS MER

7. 35. Mass Spectrometry of Biologically Active Small Molecules : Focusing on polyphenols, alkaloids and amino acids

   Författare :Zdeněk Spáčil; Leopold L. Ilag; Frantisek Turecek; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LC-MS; LDI; Mass spectrometry; HPLC; UHPLC; polyphenols; phenolic acids; BMAA; Separation methods; Separationsmetoder; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : The foci of this dissertation are on advanced liquid chromatography (LC) separation and mass spectrometry (MS) techniques for the analysis of small bioactive molecules. In addition to discussing general aspects of such techniques the results from analyses of polyphenols (PPs), alkaloids and amino acids published in five appended studies are presented and discussed. LÄS MER