Sökning: "adrenocortical tumor"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden adrenocortical tumor.

  1. 1. Adrenocortical tumors : Diagnosis, growth regulation and treatment

    Författare :Carin Backlin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Monoclonal antibodies generated by immunization with human adrenocortical cells reacted with the normal adrenal cortex, adrenocortical adenomas and carcinomas, but failed to stain a variety of normal tissues, renal cell carcinoma, and pheocromocytomas. The antibodies can be used to improve histological diagnosis and characterization of human adrenal lesions, and possibly for scintigraphic detection. LÄS MER

  3. 2. Centrosome aberrations and tumor development

    Författare :Kaoru Fujioka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Centrosome; cervical carcinoma; adrenocortical tumor; tetraploidization; p53; griseofulvin; 13-cis-retinoic acid.;

    Sammanfattning : The transformation of a normal cell to a tumor cell is a result of a failure somewhere in a complicated system of coordination, checkpoints and control mechanisms of inhibitors and activators working as triggers and transactivators of genes of importance for cell cycle progression. In the present thesis, the focus is on an important function that controls the segregation of the chromosomes during cell division to the next generation of two daughter cells. LÄS MER

  4. 3. Genetic characterization of adrenocortical tumors

    Författare :Magnus Kjellman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adrenocortical tumors; Comparative genomic hybridization; mutation analyzes; in situ hybridization; loss of heterozygosity; MEN 1;

    Sammanfattning : Adrenocortical cancer is a rare tumor form. However, adrenal tumors are today often found incidentally when using imaging techniques on the upper abdomen and should then be investigated. With the advance in molecular understanding of cancer new approaches to manage the disease may become available. LÄS MER

  5. 4. Differential RNA expression in benign and malignant adrenocortical tumours

    Författare :David Velázquez-Fernández; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adrenocortical; microarray; mRNA; cancer; tumors; cDNA; expression profiles; aldosterone; cortisol; endocrine; adenomas; carcinomas; IGF2; ALDH1A1.;

    Sammanfattning : Adrenocortical cancer is a rare but very aggressive endocrine tumor, with a yearly incidence of 0.5 to 2 cases per million inhabitants, accounting for 0.2% of all cancer related deaths. LÄS MER

  7. 5. Intraoperative scintigraphic detection of abdominal endocrine tumors : Development and evaluation of hand held gamma sensitive probes for¹¹¹In

    Författare :Ulf Öhrvall; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Adrenocortical carcinoma; endocrine pancreatic tumors; mid-gut carcinoids; intraoperative gammadetection; octreotide; scintigraphy; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Surgery of endocrine tumors benefit from accurate pre and- intraoperative localization methods,and scintigraphy has become an important contribution in this respect. In the present thesis therequisites for scintigraphic localization of abdominal endocrine tumors and new detectors forintraoperative gammadetection are evaluated. LÄS MER