Sökning: "Toxicity"

Visar resultat 11 - 15 av 965 avhandlingar innehållade ordet Toxicity.

1. 11. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications

   Författare :Caroline Haglund; Elin Lindhagen; Rolf Larsson; Anna Åleskog; Sigurd Vitols; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticancer drugs; In vitro assays; Toxicity testing; Haematological toxicity; Primary tumour cells; Species difference; Clinical pharmacology; Klinisk farmakologi; Clinical Pharmacology; Klinisk farmakologi;

   Sammanfattning : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. LÄS MER

3. 12. Internalization mechanisms of cell-penetrating peptides : Structure-activity relationships, cellular distribution and membrane toxicity studies

   Författare :Mats Hansen; Ülo Langel; Mark Lindsay; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptides; mechanisms; toxicity; structure-activity relationship; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : Transport of substances with pharmaceutical potential over the plasma membrane has been pushed a great step forward with the discovery of short cationic polypeptides, known as cell-penetrating peptides (CPP). Since then, the internalization mechanism and cargo delivery properties of CPPs has been extensively studied. LÄS MER

4. 13. Uptake and toxicity of brominated flame retardants and pesticides : Studies on littoral organisms and model communities

   Författare :Kerstin Gustafsson; Nils Kautsky; Kirsten Christoffersen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aquatic ecotoxicology; ecological interactions; indirect effects; model community studies; toxicity; Terrestrial; freshwater and marine ecology; Terrestisk; limnisk och marin ekologi;

   Sammanfattning : In this thesis, brackish and freshwater littoral model communities (microcosms) of varying size and complexity were used to study the effects of brominated flame retardants (BFRs) and pesticides. The brackish water microcosms consisted of natural water, sediment and associated organisms, while the larger freshwater microcosms also contained submersed macrophytes (Elodea canadensis). LÄS MER

5. 14. Copepods in Skeletonema-dominated food webs : Toxicity and nutritional quality as factors controlling copepod-diatom interactions

   Författare :Roswati Md Amin; Ulf Båmstedt; Sigrun Jónasdóttir; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Copepod-diatom interaction; toxicity; nutritional quality; Skeletonema;

   Sammanfattning : My thesis focuses on copepod-diatom interactions, specifically on the effects of food quality and toxicity on copepod feeding, reproductive success and behavior but as a frame, also includes a quantitative evaluation of copepod carbon requirements compared to other trophic plankton groups. My aim was to evaluate the function of copepods in diatom-dominated spring blooms. LÄS MER

7. 15. Chlorinated Paraffins: improved understanding of their bioaccumulation and toxicity in Daphnia magna

   Författare :Mafalda Castro; Magnus Breitholtz; Anna Sobek; Elena Gorokhova; Lillemor Asplund; Martin Scheringer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chlorinated paraffins; POPs; bioaccumulation; toxicity; ecotoxicology; aquatic toxicology; daphnia magna; liposomes; passive dosing; hydrophobic; mixtures; Applied Environmental Science; tillämpad miljövetenskap;

   Sammanfattning : Chlorinated paraffins (CPs) are industrial chemicals, mainly used as flame retardants, plasticizers and metal cutting fluids. Their production has reached historically high levels in the last decade, with an annual production exceeding one million tonnes. LÄS MER