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Visar resultat 1 - 5 av 965 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Towards new computational tools for predicting toxicity

   Författare :Swapnil Chavan; Ian Nicholls; Scott Boyer; Linnéuniversitetet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Acute toxicity; chronic toxicity; hERG; k-NN; LD50; LOEL; Munro database; QSAR; read-across; toxicity; Medicinsk kemi; Medical Chemistry;

   Sammanfattning : The toxicological screening of the numerous chemicals that we are exposed to requires significant cost and the use of animals. Accordingly, more efficient methods for the evaluation of toxicity are required to reduce cost and the number of animals used. LÄS MER

3. 2. Environmental and health hazards of chemicals in plastic polymers and products

   Författare :Delilah Lithner; Göteborgs universitet; []
   Nyckelord :plastics; plastic products; plastic polymers; consumer products; environmental hazards; environment; health hazards; human health; hazard ranking; hazard assessment; chemical ranking; hazard identification; hazard classifications; hazardous chemicals; hazardous substances; toxic substances; monomers; polymers; toxicity; acute toxicity; toxicity tests; Daphnia magna; Toxicity Identification Evaluation; TIE; leaching; leachates; product leachates; leaching tests; plastic materials; plastic;

   Sammanfattning : Plastics are extremely diverse in terms of chemical composition, properties and possible applications, and are widely distributed in the society and the environment. In the last 15 years the global annual production has doubled, reaching 245 million tons in 2008. LÄS MER

4. 3. Anthracyclines : Toxicity and chemotherapy-induced mucositis

   Författare :Fredrik Kullenberg; Hans Lennernäs; Erik Sjögren; David Dahlgren; Femke Heindryckx; Henrik Rönnberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anthracycline; doxorubicin; idarubicin; toxicity; intracellular concentration; IC50; chemotherapy-induced mucositis; apoptosis; proliferation; permeability; anti-inflammatory drugs; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Anthracyclines belong to a class of cytostatic compounds that are commonly used to treat various types of cancers, including lymphoma, breast cancer and primary liver cancer. The aim of this thesis was to study how two anthracyclines, doxorubicin and idarubicin, induced cytotoxicity in tumor cells, as well as their off-target effect on the gastrointestinal system. LÄS MER

5. 4. Comparative avian developmental toxicity of PFAAs

   Författare :Marcus Nordén; Magnus Engwall; Krister Halldin; Anders Bignert; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chicken; herring gull; cormorant; PFAA; PFOS; PFOA; toxicity; levels; Biology; Biologi;

   Sammanfattning : Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that can commonly be found in environmental matrixes and wildlife from all over the globe. The PFAAs have been used in applications such as water and dirt repelling treatments for textiles, oil-resistant paper coatings and fire-fighting foams. LÄS MER

7. 5. Analysis of Perfluoroalkyl Acids in Swedish Biota : Temporal trends, tissue distribution and toxicity

   Författare :Katrin Holmström; Urs Berger; Gregg Tomy; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; PFOS; PFAS; pollutant; Baltic guillemot; peregrine falcon; Monoporeia affinis; time trend; toxicity; Environmental chemistry; Miljökemi; Persistent organic compounds; Persistenta organiska föreningar; Applied Environmental Science; tillämpad miljövetenskap;

   Sammanfattning : Perfluorinated alkyl acids (PFAS) are ubiquitous environmental contaminants. They are found in high concentrations in top predators worldwide, with perfluorooctane sulfonate (PFOS) as the predominant compound. LÄS MER