Sökning: "Tissue kallikrein"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden Tissue kallikrein.

  1. 6. Leukocyte recruitment and control of vascular permeability in acute inflammation

    Författare :Ellinor Kenne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The inflammatory process is fundamental in host defense against tissue injury or infection. However, the inflammatory reaction may itself cause harm to the host and contribute to tissue damage and organ dysfunction. Leukocyte recruitment and edema formation are key components of the inflammatory response. LÄS MER

  3. 7. Microvascular effects of insulin in the skin

    Författare :Alexandra Högstedt; Simon Farnebo; Bijar Ghafouri; Erik Tesselaar; Folke Sjöberg; Sven Andersson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The microcirculation in the skin is essential for skin homeostasis. In instances of altered microvascular function, that may be the result of insulin resistance, tissue morbidity may ensue. The underlying mechanisms are however complex and not fully understood. LÄS MER

  4. 8. Endothelial Barrier Dysfunction in Multiple Organ Injury. An Experimental Study in Rats

    Författare :Xiaoming Deng; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; orthopaedics; Surgery; Endothelial barrier permeability; Multiple organ dysfunction syndrome; Zymosan; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : Multiple organ dysfunction syndrome (MODS) is still the leading cause of mortality in the surgical intensive care unit. The effect on among others endothelial barrier permeability, reticuloendothelial function, organ function and protease-antiprotease activities was studied following a variety of challenges, especially over-activation of macrophages induced by intraperitoneal administration of zymosan. LÄS MER

  5. 9. Kinin System Activation in Vasculitis

    Författare :Robin Kahn; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; kinin receptors; inflammation; vasculitis; proteinase 3; neutophils; anti-neutrophil-cytoplasmic antibodies; Kinin;

    Sammanfattning : The kinin system is activated when high-molecular-weight kininogen (HK) is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. LÄS MER

  7. 10. Inhibition of the plasma contact system on endpoint immobilized heparin and human endothelium

    Författare :Javier Augusto Sánchez Saavedra; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Contact activation system; FXII; prokallikrein; antithrombin; specific AT-binding site; immobilized heparin; heparan sulphate; endothelium;

    Sammanfattning : When blood is exposed to foreign materials or injured tissue, several defense systems are activated. The contact with an artificial surface leads to activation of FXII, the first proenzyme of the plasma contact activation system, with concomitant triggering of the intrinsic coagulation and also the fibrinolytic-, kallikrein- and complement systems. LÄS MER