Sökning: "Zymosan"
Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet Zymosan.
1. Endothelial Barrier Dysfunction in Multiple Organ Injury. An Experimental Study in Rats
Sammanfattning : Multiple organ dysfunction syndrome (MODS) is still the leading cause of mortality in the surgical intensive care unit. The effect on among others endothelial barrier permeability, reticuloendothelial function, organ function and protease-antiprotease activities was studied following a variety of challenges, especially over-activation of macrophages induced by intraperitoneal administration of zymosan. LÄS MER
2. Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
Sammanfattning : Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. LÄS MER
3. Signalling to Activation of Cytosolic Phospholipase A2 and Arachidonate Release in Macrophages
Sammanfattning : Eicosanoids include prostaglandins, thromboxanes and leukotrienes, which are arachidonic acid oxygenation products. These lipids make important contributions to the signs and symptoms of inflammatory diseases. LÄS MER
4. Molecular targets for glucocorticoids in macrophages: cytosolic phospholipase A2 and cytokine formation
Sammanfattning : The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. LÄS MER
5. Mass spectrometric investigation of protein nitration in inflammation and neurodegeneration
Sammanfattning : The nitration of tyrosine seems to be very common in human diseases and at least forty different diseases have been reported to be associated with an increased nitration of proteins. The nitration of proteins results in a modification of tyrosine, 3-nitrotyrosine (3-NT), which is stable. LÄS MER