Sökning: "T regulatory lymphocytes"
Visar resultat 16 - 20 av 106 avhandlingar innehållade orden T regulatory lymphocytes.
16. The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy
Sammanfattning : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. LÄS MER
17. Regulatory T cells : molecular and clinical aspects
Sammanfattning : In the immune system’s tug of war with cancer, tolerance mechanisms by which the tumor can control anti-tumor immune responses play a central role in determining the outcome. Regulatory T cells (Treg) induced in the thymus or the periphery, represent one such tolerance mechanism that potentially can be exploited by developing tumors. LÄS MER
18. Immune maturation and lymphocyte characteristics in relation to early gut bacteria exposure
Sammanfattning : At birth, the immune system is immature and the gut microbiota influences immune maturation. Staphylococcus aureus (S. aureus) and lactobacilli are part of the neonatal gut microbiota and have seemingly opposite effects on the immune system. S. LÄS MER
19. The immortalization process of T cells : with focus on the regulation of telomere length and telomerase activity
Sammanfattning : Cellular immortalization is a major hallmark of cancer and is a multi-step process that requires numerous cell-type specific changes, including inactivation of control mechanisms and stabilization of telomere length. The telomeres at the chromosome ends are essential for genomic stability, and limit the growth potential of most cells. LÄS MER
20. Towards Immunotherapy of Midgut Carcinoid Tumors
Sammanfattning : Classical midgut carcinoids belong to neuroendocrine tumors of the gastroenteropancreatic tract (GEP-NETs) and are associated with serotonin overproduction. The term midgut is derived from the tumors’ embryological site of origin: enterochromaffin cells in the lower jejunum, ileum, caecum and the ascending colon. LÄS MER