Sökning: "immune-maturation"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet immune-maturation.

1. 1. Immune maturation and lymphocyte characteristics in relation to early gut bacteria exposure

   Författare :Sophia Björkander; Eva Sverremark Ekström; Hanne Frøkiær; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Allergy; cell-free supernatant; chemokines; colonization; cytokines; FOXP3; immune-maturation; lactobacilli; lymphocytes; NK-cells; Staphylococcus aureus; unconventional T-cells; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : At birth, the immune system is immature and the gut microbiota influences immune maturation. Staphylococcus aureus (S. aureus) and lactobacilli are part of the neonatal gut microbiota and have seemingly opposite effects on the immune system. S. LÄS MER

3. 2. Immune maturation and modulation in childhood allergies : Aspects of epigenetic, mucosal and systemic immune mediators in allergy development and prevention

   Författare :Johanna Huoman; Maria Jenmalm; Lennart Nilsson; Petra Ina Pfefferle; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The prevalence of allergic diseases has in the past century increased among children in affluent societies. Underlying causes are incompletely disentangled, but decreased diversity in environmental and microbial exposures could drive allergy development. LÄS MER

4. 3. Immune maturation in early childhood and the influence of herpesvirus infections

   Författare :Ebba Sohlberg; Eva Sverremark-Ekström; Eleanor Riley; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Immune differentiation; monocytes; NK cells; B cells; T cells; Epstein-Barr virus; EBV; cytomegalovirus; CMV; IFN-γ; immunologi; Immunology;

   Sammanfattning : The quality of immune responses develops from birth into adulthood and in the context of the host microbial environment. The aim of this work was to study immune maturation during childhood, and how this process can be affected by the common herpesviruses; Epstein-Barr virus (EBV) and cytomegalovirus (CMV). LÄS MER

5. 4. Maternal and neonatal metabolomes and their associations to immune maturation and allergy in early life

   Författare :Olle Hartvigsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Untargeted Metabolomics; allergy; QC; quality control; plasma; umbilical cord; placenta; LC-MS; immune system;

   Sammanfattning : Allergy, one of the most common chronic diseases worldwide, is caused by a dysregulated immune system reacting to normally harmless proteins. However, regulating mechanisms are not well understood. The aim of this thesis was to investigate if plasma and placenta metabolites associate prospectively to allergy development and immune maturation. LÄS MER

7. 5. Early-life gut microbiota and breast milk oligosaccharides in relation to childhood immune maturation and allergy

   Författare :Ylva Margareta Sjögren; Eva Sverremark-Ekström; Outi Vaarala; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; allergy; infant; gut microbiota; human milk oligosaccharides; Bifidobacterium; Lactobacillus; Bacteroides fragilis; Clostridium difficile; family size; secretory IgA; toll like receptor; Immunology; Immunologi; immunologi; Immunology;

   Sammanfattning : Atopic allergy is the most common chronic disease among children in the developed world. This high prevalence could be associated with low microbial exposure. The early gut microbiota appears to be important for immune maturation. LÄS MER