Sökning: "midgut carcinoid"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden midgut carcinoid.

  1. 1. Midgut Carcinoid Tumours : New Diagnostic Procedures and Treatment

    Författare :Staffan Welin; Eva T. Janson; Barbro Eriksson; Larry Kvols; Uppsala universitet; []
    Nyckelord :Medicine; Midgut carcinoid tumour; Chromogranin A; Carcinoid heart disease; Survival; Octreotide pamoate; Tyrosine kinase receptors; Platelet derived growth factor receptor; Epidermal growth factor receptor; Medicin;

    Sammanfattning : Midgut carcinoid tumours are rare with an incidence of 0.5-2.1/100 000. The primary tumour is usually small and grows slowly but has almost always set metastases at diagnosis. LÄS MER

  3. 2. Midgut carcinoid tumors : aspects on symptoms, surgery and survival

    Författare :Charalampos Charlie Makridis; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 3. Towards Immunotherapy of Midgut Carcinoid Tumors

    Författare :Sofia Vikman; Thomas Tötterman; Valeria Giandomenico; Bengt Widegren; Uppsala universitet; []
    Nyckelord :Immunology; midgut carcinoid; gene expression; immunotherapy; tumor antigen; VMAT-1; T cell; HLA-A*0201-binding peptide; IFNγ; regulatory T cell; Immunologi;

    Sammanfattning : Classical midgut carcinoids belong to neuroendocrine tumors of the gastroenteropancreatic tract (GEP-NETs) and are associated with serotonin overproduction. The term midgut is derived from the tumors’ embryological site of origin: enterochromaffin cells in the lower jejunum, ileum, caecum and the ascending colon. LÄS MER

  5. 4. Midgut carcinoid tumours - biochemical and therapeutic aspects

    Författare :Gunnel Westberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; carcinoid syndrome; valvular heart disease; 5-HT; chromogranins; octreotide; hepatic arterial embolization;

    Sammanfattning : The biology of human midgut carcinoid tumour was studied experimentally in primary cell culture and clinically in patients with the midgut carcinoid syndrome. In cell cultures, tumour cells had a secretory pattern of 5-HTP, 5-HT and 5-HIAA specific for each tumour indicating individual regulation of synthesis/degradation. LÄS MER

  7. 5. Tumour Biological Factors Characterizing Metastasizing Serotonin-producing Ileocaecal Carcinoids

    Författare :Janet Lynn Cunningham; Eva Tiensuu Janson; Kjell Öberg; Irvin M. Modlin; Uppsala universitet; []
    Nyckelord :Internal medicine; endocrine tumour; midgut carcinoid; serotonin-producing neuroendocrine carcinoma; prognosis; morphology; tachykinin; connective tissue growth factor; islet autoantigen-2; morphology; carcinoid syndrome; Invärtesmedicin;

    Sammanfattning : In this study, metastasizing serotonin-producing ileocaecal carcinoid tumours (MSPCs) were examined for biological characteristics that could be used to define clinically relevant subgroups within this patient population. Possible targets for new treatment options were also explored. LÄS MER