Sökning: "Structure-Activity Relationships SAR"
Visar resultat 6 - 10 av 13 avhandlingar innehållade orden Structure-Activity Relationships SAR.
6. Novel inhibitors of Chlamydia trachomatis virulence
Sammanfattning : Chlamydia trachomatis is an obligate intracellular bacterium that infects over 100 million people globally every year. Chlamydia infections can be persistent, cause infertility and blindness, adding an economical burden in the healthcare systems. LÄS MER
7. Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization
Sammanfattning : It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and current therapies are still based on this mechanism. However, all available antidepressants today are still suffering from slow onset of therapeutic action, as well as adverse effects and lack of efficacy. LÄS MER
8. Design, Synthesis, and Structure-Activity Relationships Analysis of Potential Inhibitors of the Serine Protease Thrombin and the Malarial Aspartic Proteases Plasmepsin I and II
Sammanfattning : The design, synthesis, and structure-activity relationships analysis of some potential protease inhibitors are outlined in this thesis. In particular, the serine protease thrombin and the malarial aspartic proteases plasmepsin I and II (Plm I and II) are described in regard to the roles they play in living organisms, and that is followed by discussions concerning the design, synthesis, and biological test results of inhibitors of these enzymes. LÄS MER
9. Natural Products as Leads for Pharmaceutically Active Compounds
Sammanfattning : In the search for new pharmaceutically active compounds, it is recognized that Nature produces structurally different compounds in a great variety. By having the compounds or extracts tested in defined systems, new drugs or more often leads (a compound that has an interesting but moderate activity) can be found. LÄS MER
10. SAR Studies of Capsazepinod Bronchodilators. The A-ring and the Coupling region
Sammanfattning : Bronchoconstriction is a hallmark in respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Current therapies use bronchodilating agents in order to control the exacerbations produced by limited airflow and improve the quality of life of patients suffering from these diseases. LÄS MER
