Sökning: "Seizures"

Visar resultat 11 - 15 av 125 avhandlingar innehållade ordet Seizures.

  1. 11. Pharmacometric Methods and Novel Models for Discrete Data

    Författare :Elodie L Plan; Mats O Karlsson; Laura Sargentini-Maier; Armel Stockis; Christian Laveille; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacodynamics; disease progression; modelling; discrete data; count; ordered categorical; repeated time-to-event; RTTCE; RCEpT; NONMEM; FOCE; LAPLACE; SAEM; AGQ; pain scores; epilepsy seizures; gastroesophageal symptoms; statistical power; simulations; diagnostics; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Pharmacodynamic processes and disease progression are increasingly characterized with pharmacometric models. However, modelling options for discrete-type responses remain limited, although these response variables are commonly encountered clinical endpoints. Types of data defined as discrete data are generally ordinal, e.g. LÄS MER

  3. 12. Lithium and brain plasticity - studies on glial cell changes and electroconvulsive treatment-induced amnesia in rats

    Författare :Karin Orre; Enheten för psykiatrisk neuromodulering (PNU); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lithium; electroconvulsive seizures; mood disorder; gliogenesis; amnesia; oligodendrogenesis; myelination; NG2 cells;

    Sammanfattning : Depression and bipolar disorder, collectively known as mood disorders, are devastating, common and often chronic illnesses. Imaging studies of patients with mood disorders have demonstrated structural changes in several brain regions implicated in mood regulation. LÄS MER

  4. 13. Modulation of angiogenesis in adult rat brain - effect of aging, stress, environmental enrichment and antidepressant treatment

    Författare :Joakim Ekstrand; Enheten för psykiatrisk neuromodulering (PNU); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; corticosterone; enrichment; electroconvulsive seizures; Angiogenesis; neurogenesis;

    Sammanfattning : Neurogenesis and angiogenesis are stimulated by a number of antidepressant treatments, and cellular plasticity has emerged as a phenomenon with great relevance to the etiology and treatment of depression. In paper I we characterize how ECS-induced endothelial cell proliferation leads to vascularization of the adult rat hippocampus. LÄS MER

  5. 14. Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry

    Författare :Fredrik Berglind; Epilepsicentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Seizure; epileptogenesis; optogenetics; NpHR; ChR2; DREADD; hippocampus; in vivo; mouse;

    Sammanfattning : Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmaceuticals. LÄS MER

  7. 15. Temperature management after cardiac arrest, postanoxic injury and neurological recovery

    Författare :Anna Lybeck; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac arrest; target temperature mangement; outcome; neuroprognostication; seizures; EEG; Cardiac arrest; target temperature mangement; outcome; neuroprognostication; seizures; EEG;

    Sammanfattning : In patients admitted alive to hospital after cardiac arrest the most common mode of death is withdrawal of life sustaining therapy due to brain injury. This decicion is preceeed by multimodal neuroprognostication, which includes clinical examination, neurophysiological tests, imagning and serum markers of braininjury. LÄS MER