Sökning: "DREADD"
Hittade 3 avhandlingar innehållade ordet DREADD.
1. Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry
Sammanfattning : Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmaceuticals. LÄS MER
2. Striatal pathways in dyskinesia and dystonia
Sammanfattning : Purposeful and well-coordinated movements depend on the control exerted by dopamine (DA) on the basal ganglia (BG) network. Accordingly, dysfunctions or lesions of the dopaminergic system in the BG can result in an overall poverty and slowness of movement, cardinal features of Parkinson´s disease (PD), or in dyskinesias, exaggerated and involuntary movements resulting from L-DOPA pharmacotherapy. LÄS MER
3. Somatosensory Circuits in the Central Nervous System
Sammanfattning : Spinal glycinergic neurons prevent spontaneous sensations of pain and itch, and development of persistent pain and itch conditions. The glycine receptor alpha 3 subunit (GLRA3) is suggested to be involved in certain inflammatory models, but not in acute nociception. LÄS MER