Sökning: "SELDI-TOF-MS"

Visar resultat 6 - 10 av 10 avhandlingar innehållade ordet SELDI-TOF-MS.

  1. 6. Disturbed Islet Function and Alterations in Islet Protein Expression

    Författare :Henrik Ortsäter; Peter Bergsten; Franz Schuit; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell biology; islet; glucose; oleate; corticosterone; oxygen tension; insulin release; protein profiling; Clark-like electrodes; SELDI-TOF MS; PPI-B; 11β-HSD1; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : Pancreatic β-cells sense the concentration of glucose in the systemic circulation through metabolism of the sugar molecule. Failure to correlate the blood sugar concentration to an appropriate metabolic signal disrupts the function of the β-cell as a controller of glucose homeostasis and may contribute to the development of type 2 diabetes mellitus. LÄS MER

  3. 7. In search of diagnostic and prognostic markers for thyroid cancer : a proteomics approach

    Författare :Anastasios Sofiadis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thyroid tumors; thyroid proteomics; S100A6; MIB-1; 2DE; MALDI-TOF-MS; SELDI-TOF-MS; protein pre-fractionation;

    Sammanfattning : Early diagnosis of cancer can influence the therapeutic strategy increasing the chances of cure or, at least, prolonged survival. It is equally important to be able to detect prognostic signs, i.e. tumor features that characterize its behavior. LÄS MER

  4. 8. Multivariate analyses of proteomic and metabolomic patterns in brain tumors

    Författare :Carl Wibom; A Tommy Bergenheim; Henrik Antti; Mikael Johansson; Janne Lehtiö; Umeå universitet; []
    Nyckelord :glioblastoma; meningioma; proteomics; metabolomics; multivariate analyses; onkologi; Oncology;

    Sammanfattning : Glioblastoma multiforme (GBM) is the most common primary brain tumor. Given the current standard of care, the prognosis for patients diagnosed with this disease is still poor. There consequently exists a need to improve current treatments, as well as to develop new ones. LÄS MER

  5. 9. Cancer proteomics : method development for mass spectrometry based analysis of clinical materials

    Författare :Maria Pernemalm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : To improve cancer treatment, biomarkers for diagnostics and therapeutic guidance are desperately needed. Mass spectrometry (MS) based proteomics is one of the most promising methods for biomarker discovery. Clinical materials such as blood and tumor tissue provide an excellent starting material for biomarker discovery studies. LÄS MER

  7. 10. Metabolomics and proteomics studies of brain tumors : a chemometric bioinformatics approach

    Författare :Lina Mörén; Henrik Antti; Anders Malmendal; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; glioma; meningioma; metabolomics; proteomics; mass-spectrometry; biologisk kemi; biological chemistry;

    Sammanfattning : The WHO classification of brain tumors is based on histological features and the aggressiveness of the tumor is classified from grade I to IV, where grade IV is the most aggressive. Today, the correlation between prognosis and tumor grade is the most important component in tumor classification. LÄS MER