Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet S100A6.
1. Proteomic analysis of DNA damage induced stress signaling with focus on p53 : S100A6 regulation, function and potential as biomarker in lung cancer and as a novel therapeutic target
Sammanfattning : In this thesis powerful proteomics methods were used to reveal novel proteins involved in the cellular response to DNA damaging treatment. The goal was to find proteins with potential as biomarkers for prediction of cancer prognosis and response to cancer therapy, but also to find potential novel targets of cancer therapy. LÄS MER
Sammanfattning : Early diagnosis of cancer can influence the therapeutic strategy increasing the chances of cure or, at least, prolonged survival. It is equally important to be able to detect prognostic signs, i.e. tumor features that characterize its behavior. LÄS MER
Sammanfattning : Lung cancer is a disease characterized by high incidence and mortality rates as well as by a remarkable resistance to common treatment strategies. Reliable and validated biomarkers could represent a possible breakthrough in the management of this tumor type, by facilitating diagnosis, refining prognosis and providing guidance towards the choice of the most appropriate therapy. LÄS MER
Sammanfattning : Papillary thyroid carcinoma (PTC) exhibits various molecular abnormalities, both when sporadic and radiation-related. PTC is still diagnosed in adult individuals who were younger than 18 years at the time of the Chornobyl accident in 1986 and lived within the contaminated area. LÄS MER
5. Challenges in the management of urothelial cancer : novel treatment, evaluation of biomarkers, and imaging techniques
Sammanfattning : Urothelial cancer (UC) is the most common malignancy found in the urinary tract. The global annual incidence is approximately 430 000 new cases (Sweden: 3 200 new cases). Approximately one in four new UC patients being diagnosed has muscle-invasive disease. LÄS MER