Sökning: "Thyroid tumors"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden Thyroid tumors.

  1. 1. Molecular genetic studies of human thyroid tumors

    Författare :Tony Frisk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Follicular thyroid tumors; tumor progression; Cowden disease; PTEN; CGH; RET; medullary thyroid carcinoma; MEN 2; anaplastic carcinoma.;

    Sammanfattning : Tumors of the thyroid gland are common among the general population, but only a small proportion is malignant. The vast majority of thyroid tumors are benign, so called follicular adenomas. Sometimes subtypes such as atypical adenomas and adenomas with oxyphil, i.e. LÄS MER

  2. 2. Behind the scenes of thyroid tumors : underlying genetic mechanisms

    Författare :Jia Jing Lee; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Familial medullary thyroid cancer; follicular thyroid cancer; anaplastic thyroid cancer; CCND1; UBCH10; p16; RASSF1A; BRAF; array-CGH; tumor progression; global methylation; LINE-1; LUMA;

    Sammanfattning : Thyroid cancer is the most frequently observed malignancy involving endocrine tissues. This group of diseases is also the major cause of death related to neoplasia of the endocrine system. Tumors in the thyroid gland are common in the general population and the majority represents benign follicular adenoma (FTA). LÄS MER

  3. 3. Reversal of thyroid dedifferentiation and an invasive phenotype by small molecule kinase inhibitors: an experimental study on normal and malignant cells

    Författare :Camilla Ingeson-Carlsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thyroid; cancer; NIS; MAPK; PI3K; BRAFV600E; migration; 3D culture;

    Sammanfattning : Refractoriness to I-131 in dedifferentiated thyroid cancer is a great concern that restricts radioiodine therapy. There is also a lack of knowledge in understanding the mechanisms leading to repressed sodium iodide symporter (NIS) expression and impaired iodide uptake in tumor cells. LÄS MER

  4. 4. Taking Pressure of Anaplastic Thyroid Carcinoma : Molecular Studies of Apoptosis and Interstitial Hypertension

    Författare :Pernilla Roswall; Nils-Erik Heldin; Kristofer Rubin; Sven Påhlman; Uppsala universitet; []
    Nyckelord :Medicine; Anaplastic thyroid carcinoma; Apoptosis; Cre recombinase; 2-Methoxyestradiol; Transforming growth factor-β; Transgenic mouse; Tumor-associated macrophages; Tumor interstitial fluid pressure; Medicin;

    Sammanfattning : Molecular mechanisms in the development and progression of thyroid carcinomas are still not fully understood. In the present thesis the highly malignant anaplastic thyroid carcinoma (ATC) was used to study regulation of apoptosis and tumor interstitial fluid pressure (IFP). LÄS MER

  5. 5. Immunological aspects of papillary thyroid carcinoma

    Författare :Steven D. Lucas; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Papillary thyroid carcinoma; immunology; tumor antigens; RET proto-oncogene; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Papillary thyroid carcinoma (PTC) is a puzzling disease. Although approximately 70% of patients with PTC have regional lymph node metastases at initial surgery, the long term survival is over 95%. LÄS MER