Sökning: "RCR"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet RCR.

  1. 1. Padlock Probes and Rolling Circle Amplification : New Possibilities for Sensitive Gene Detection

    Författare :Maritha Mendel-Hartvig; Pål Nyrén; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Padlock probes; RCR; in situ hybridization; branched DNA; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : A series of novel methods for detection of known sequence variants in DNA, in particular single nucleotide polymorphism, using padlock probes and rolling circle replication are presented. DNA probes that can be circularized – padlock probes – are ideal for rolling circle replication. LÄS MER

  2. 2. Radiobiological end-points for the theoretical evaluation of the effectiveness of carbon ions and photons in treating tumours with dynamic hypoxia

    Författare :Antonovic Laura; Iuliana Toma-Dasu; Tatsuaki Kanai; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; OER; hypoxia; LOC; RCR; hypofractionation; SBRT; carbon ion; fractionation; TCP; SF; RCE; RBE; medicinsk strålningsfysik; Medical Radiation Physics;

    Sammanfattning : Tumours are characterised by unorganised vasculature, which often results in hypoxic regions. Hypoxia is a common cause for photon radiotherapy (RT) treatment failure, as hypoxic cells require up to 2-3 times higher doses compared to well-oxygenated cells for the same effect in terms of cell kill. LÄS MER

  3. 3. From cell survival to dose response : modeling biological effects in radiation therapy

    Författare :Minna Wedenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Radiobiological models;

    Sammanfattning : The main goal in curative radiation therapy is to eradicate the tumor while minimizing radiation-induced damage to normal tissue. Ions, including protons and carbon ions, are increasingly being used for cancer treatment. LÄS MER

  4. 4. Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling

    Författare :Katarzyna Zielinska-Chomej; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Cancer is, despite rapid progress in development of new targeted therapies, still mainly treated with surgery, chemotherapy and/or radiation therapy. The last two mentioned conventional therapies often meet general obstacles such as normal cell toxicity and tumour cell resistance. LÄS MER

  5. 5. Different approaches to develop radio- and chemotherapy for treatment of human cancer

    Författare :Chitralekha Mohanty; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Despite huge advancements in our knowledge and understanding of the molecular mechanisms of carcinogenesis, the prognoses of many malignant diseases have not improved dramatically. Improvements in the therapeutic efficacy of several anti-cancer therapies including radiotherapy and chemotherapy would be required to achieve effective treatment. LÄS MER