Sökning: "branched DNA"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden branched DNA.

  1. 1. Porphyrin Anchored DNA: Advances in DNA Nanotechnology

    Författare :Jakob Woller; Chalmers University of Technology; []
    Nyckelord :;

    Sammanfattning : DNA nanotechnology has focused on the creation of complex structures using DNA as building blocks. DNA is an attractive construction material at the nano scale due to the self-assembly and specific base-pairing of the DNA bases, allowing the placement of functional groups with sub-nm precision. LÄS MER

  3. 2. Padlock Probes and Rolling Circle Amplification : New Possibilities for Sensitive Gene Detection

    Författare :Maritha Mendel-Hartvig; Pål Nyrén; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Padlock probes; RCR; in situ hybridization; branched DNA; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : A series of novel methods for detection of known sequence variants in DNA, in particular single nucleotide polymorphism, using padlock probes and rolling circle replication are presented. DNA probes that can be circularized – padlock probes – are ideal for rolling circle replication. LÄS MER

  4. 3. DNA double-strand break repair in ascomycetes

    Författare :Jiang Chen; Stefan Åström; Michael Lisby; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; utvecklingsbiologi; Developmental Biology;

    Sammanfattning : Nonhomologous end joining (NHEJ) and homologous recombination (HR) are two pathways for DNA double strand break (DSB) repair. We found that the NHEJ protein Nej1 interacted physically with the HR protein Srs2, which was dependent on phosphorylation of Nej1 by Dun1. Srs2 recruitment to a DSB partly relied on Nej1 and Dun1. LÄS MER

  5. 4. Studies on nucleic acids chemistry

    Författare :Nitin Puri; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi; bioorganisk kemi; Biorganic Chemistry;

    Sammanfattning : This thesis is divided into three parts: Part 1: Synthesis and conformational analysis of cyclic RNAs, and comparison with lariat RNAs modelling the lariat formed during processing of Group II and Nuclear pre-mRNA. Synthesis of a hexameric lariat RNA model with a tetranucleotidyl "2' → 5' loop" and a dinucleotidyl "3'-tail" has been accomplished. LÄS MER

  7. 5. Malnutrition in patients with chronic renal failure

    Författare :Abdul Rashid Tony Qureshi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; chronic renal failure; malnutrition; serum albumin; hand-grip strength; amino acids; inflammation;

    Sammanfattning : Protein-energy malnutrition is common in patients with chronic renal failure (CRF) and may contribute to a poor clinical outcome. However, the role of nutrition in this regard has not been clearly defined. LÄS MER