Sökning: "Protofibrils"

Visar resultat 11 - 15 av 18 avhandlingar innehållade ordet Protofibrils.

1. 11. Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders

   Författare :Therese Fagerqvist; Martin Ingelsson; Joakim Bergström; Lars Lannfelt; Michael G Schlossmacher; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha-synuclein; Parkinson´s disease; Lewy body dementia; Oligomer; Monoclonal antibody; Immunotherapy; Reactive aldehydes; Medical Science; Medicinsk vetenskap;

   Sammanfattning : The protein alpha-synuclein (α-synuclein) accumulates in the brain in disorders such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). It is believed that the monomeric form of α-synuclein can adopt a partially folded structure and start to aggregate and form intermediately sized oligomers or protofibrils. LÄS MER

3. 12. DNA-Mediated Detection and Profiling of Protein Complexes

   Författare :Maria Hammond; Ulf Landegren; Masood Kamali-Moghaddam; Christof Niemeyer; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proximity ligation assay; Protein complexes; Protein interactions; Biomarkers; Prions; Antibodies; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Proteins are the effector molecules of life. They are encoded in DNA that is inherited from generation to generation, but most cellular functions are executed by proteins. Proteins rarely act on their own – most actions are carried out through an interplay of tens of proteins and other biomolecules. LÄS MER

4. 13. Enhancing the therapeutic effect of biological drugs with protein engineering : Focusing on pre-clinical Alzheimer’s disease therapy

   Författare :Fadi Rofo; Greta Hultqvist; Stina Syvänen; Sara Mangsbo; Joy Zuchero; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; amyloid-beta; blood-brain barrier; transferrin receptor; protein-drugs; multivalent-bispecific antibodies;

   Sammanfattning : Aggregation of the amyloid-β peptide (Aβ) is one of the main pathological hallmarks in Alzheimer’s disease (AD). The soluble Aβ aggregates (oligomers and protofibrils) have shown to be the most harmful species. Hence, targeting these aggregates can be of therapeutic potential. LÄS MER

5. 14. Pathogenic Mechanisms of the Arctic Alzheimer Mutation

   Författare :Charlotte Sahlin; Lars Lannfelt; Lars Nilsson; Christian Haass; Uppsala universitet; []
   Nyckelord :Neurosciences; Alzheimer s disease; Arctic mutation; Amyloid precursor protein; Amyloid-β; APP processing; Aβ oligomers; Docosahexaenoic acid; Neurovetenskap;

   Sammanfattning : Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, neuropathologically characterized by neurofibrillay tangles and deposition of amyloid-β (Aβ) peptides. Several mutations in the gene for amyloid precursor protein (APP) cause familial AD and affect APP processing leading to increased levels of Aβ42. LÄS MER

7. 15. Proximity Ligation and Barcoding Assays : Tools for analysis of proteins and protein complexes

   Författare :Di Wu; Masood Kamali-Moghaddam; Ulf Landegren; Ola Söderberg; Jörg Hoheisel; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; proximity barcoding assay; sensitive; in situ; multiplex; profiling; amyloid-beta; MARK; tau; CSF; biomarker; protein complexes; Alzheimer’s disease; amyotrophic lateral sclerosis; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. LÄS MER