Sökning: "Prion"

Visar resultat 21 - 25 av 55 avhandlingar innehållade ordet Prion.

1. 21. Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line

   Författare :Malin Sandberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Prion; Scrapie; Voltage-gated N-type calcium channels; SNARE proteins; Exocytosis; Long-term depolarization;

   Sammanfattning : The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs including dementia, ataxia and myoclonus. These diseases cause characteristic electroencephalographic changes. LÄS MER

3. 22. Characterization of the prion protein in relation to normal cellular function and in disease

   Författare :Lotta Wik; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of rare and fatal neurodegenerative disorders that can affect both human and animals. Evidence indicates that the key event in prion disease pathogenesis is the conformational conversion of the normal cellular prion protein (PrPC) into an aggregated isoform called the scrapie prion protein (PrPSc). LÄS MER

4. 23. Neuropeptide expression in mouse disease models

   Författare :Margarita Diez; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alzheimers disease; autoradiographic ligand binding; CCK; degeneration; dynorphin; enkephalin; galanin; immunohistochemistry; in situ hybridization; lesion; magnetic resonance imaging; megencephaly; NPY; prion infection; substance P.;

   Sammanfattning : The role of neuropeptides and the significance of peptidergic mechanisms in neurodegenerative diseases are still relatively unexplored. In the periphery, nerve injury results in dramatic changes in the expression of neuropeptides (and other molecules). LÄS MER

5. 24. Intracellular pathways involved in formation and degradation of prions

   Författare :Elin Allard; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Prions cause invariably fatal neurodegenerative diseases, in which a misfolded host-encoded protein appears to be the main, if not the only, component of the infectious agent. During disease, a normal cellular protein, PrPC, is converted to a disease-related isoform, PrPSc, by a post-translational process that might require auxiliary cellular cofactors. LÄS MER

7. 25. Early events in disease associated protein misfolding

   Författare :Sofie Nyström; Per Hammarström; Marcus Fändrich; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi;

   Sammanfattning : The scope of this thesis is to unravel some of the mysteries concerning events takingplace early in the amyloid cascade. In vitro studies of early misfolded states ofamyloidogenic proteins are important since the use of recombinant proteins allow us to monitor slight changes in environmental conditions as well as in amino acid composition and thereby illuminate the problem at near atomic resolution. LÄS MER