Sökning: "Prion"

Visar resultat 16 - 20 av 55 avhandlingar innehållade ordet Prion.

  1. 16. Changed iron metabolism and iron toxicity in scrapie-infected neuroblastoma cells

    Författare :Sandra Zetterström Fernaeus; Tiit Land; Gaetano Cairo; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prion disease; oxidative stress; iron metabolism; Neurochemistry; Neurokemi;

    Sammanfattning : Reactions and interactions of iron and oxygen can be both beneficial and detrimental to cells and tissues. Iron is mainly found in our blood where it functions as a mediator in the transport of oxygen to the cells and is further vital for the cellular respiration reducing the oxygen to water. LÄS MER

  3. 17. Molecular changes in scrapie-infected neuroblastoma cells

    Författare :Pernilla Östlund; Stockholms universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Prion diseases; Scrapie; Infection; Neuroblastoma; Får sjukdomar; Prioner; Hjärna; Husdjurslära;

    Sammanfattning : .... LÄS MER

  4. 18. A Theoretical Investigation of the Octapeptide Region in the Human Prion Protein

    Författare :Eva-Stina Riihimäki; Lars Kloo; José Manuel Martínez; Francisco Javier Luque Garriga; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; prion protein; copper; octapeptide; structure; force field parameters; coordination; non-periodic boundary conditions; Inorganic chemistry; Oorganisk kemi;

    Sammanfattning : Den kopparbindande egenskapen hos prionproteiner är sannolikt kopplad till proteinets funtion. Det mänskliga prionproteinet innehåller ett kopparbindande oktapeptidområde, där PHGGGWGQ-sekvensen upprepas fyra gånger i följd. LÄS MER

  5. 19. Genetic studies of neurological disorders : Rett syndrome and HD-like familial prion disease

    Författare :Fengqing Xiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Huntington s disease HD ; MECP2 gene; mutation; linkage analysis; prion disease; prion protein PrP ; Rett syndrome RTT ; X-chromosome inactivation XCI .;

    Sammanfattning : Rett syndrome (RTT) is a severe childhood neurodevelopmental disorder, which almost exclusively affects females with a prevalence of 1 in 10 000-15 000, >99% of the cases are sporadic. It is commonly thought of as an X-linked dominant disorder lethal to males. LÄS MER

  7. 20. Interactions of Prion Proteins and PrP-derived Peptides in Scrapie infection

    Författare :Kajsa Löfgren Söderberg; Astrid Gräslund; Marcus Fändrich; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Spongiform encephalopathy; Creutzfeldt-Jakob disease; Amyloidosis; Neurodegeneration; Cell penetrating peptide; Protein Transduction Domain; Heparan sulfate; Proteoglycan; Glypican; Src family kinase; Fyn; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Prion diseases are fatal and incurable spongiform encephalopathies that occur amongst mammals. The central pathological event is the misfolding of the cellular prion protein (PrPC) into an amyloid, neurotoxic isoform called scrapie (PrPSc). PrPSc is the main, or sole, constituent of infectious prions. LÄS MER