Sökning: "prion infection"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden prion infection.

  1. 1. Prion-infection and Cellular Signaling : Influence of scrapie-infection on lipid raft-associated proteins

    Författare :Hanna Gyllberg; Katarina Bedecs; Albert Taraboulos; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Prion diseases are a group of fatal neurodegenerative diseases affecting almost all mammals including humans. The diseases are caused by formation of the misfolded isoform of the cellular prion protein (PrPC) to the disease causing PrPSc. LÄS MER

  3. 2. Molecular changes in scrapie-infected neuroblastoma cells

    Författare :Pernilla Östlund; Stockholms universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Prion diseases; Scrapie; Infection; Neuroblastoma; Får sjukdomar; Prioner; Hjärna; Husdjurslära;

    Sammanfattning : .... LÄS MER

  4. 3. Novel endogenous mechanisms of complement regulation - A delicate balance

    Författare :Andreas Holmér; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; short leucine rich glycoprotein; factor H; C1q; age-related macular degeneration; C4b-binding protein; prion disease; prion protein; Complement regulation; C-reactive protein;

    Sammanfattning : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. LÄS MER

  5. 4. Interactions of Prion Proteins and PrP-derived Peptides in Scrapie infection

    Författare :Kajsa Löfgren Söderberg; Astrid Gräslund; Marcus Fändrich; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Spongiform encephalopathy; Creutzfeldt-Jakob disease; Amyloidosis; Neurodegeneration; Cell penetrating peptide; Protein Transduction Domain; Heparan sulfate; Proteoglycan; Glypican; Src family kinase; Fyn; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Prion diseases are fatal and incurable spongiform encephalopathies that occur amongst mammals. The central pathological event is the misfolding of the cellular prion protein (PrPC) into an amyloid, neurotoxic isoform called scrapie (PrPSc). PrPSc is the main, or sole, constituent of infectious prions. LÄS MER

  7. 5. Altered cell signaling linked to neurodegeneration : Studies on scrapie-infected neuroblastoma cells and activated microglia

    Författare :Christina Svensson; Tiit Land; Gianluigi Forloni; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prion disease; Inflammation; MAPK; Microglia activation; Neuroblastoma; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Sammanfattning : Prion diseases are neurodegenerative disorders that can affect humans and animals. The underlying event is a conformational change of the normal cellular prion protein (PrPC) into an aberrant isoform termed PrP-scrapie (PrPSc). PrPSc is thought to lead to neurodegeneration and activation of glial cells. LÄS MER