Sökning: "Phenotyping"

Visar resultat 6 - 10 av 72 avhandlingar innehållade ordet Phenotyping.

  1. 6. Phenotyping of severe asthma in a clinical context

    Författare :Valentyna Yasinska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Severe asthma is a chronic heterogeneous inflammatory disease characterized by several clinical phenotypes and molecular endotypes. Although it affects a relatively small proportion of the asthma population (approximately 4%-10%), with an even smaller proportion of these having severe uncontrolled eosinophilic asthma, it accounts for > 50% of the costs attributed to the disease. LÄS MER

  3. 7. Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology

    Författare :Umit Yasar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CYP2C9 polymorphism; phenotyping; genotyping; diclofenac; losartan;

    Sammanfattning : Cytochrome P450 2C9 (CYP2C9) is one of the most important drug metabolizing enzymes in human liver. It catalyses the metabolism of a wide range of different drugs such as S-warfarin, acenocoumarol, losartan, irbesartan, phenytoin, sulphamethoxazole, tolbutamide, glipizide and numerous non-steroidal antiinflammatory drugs. LÄS MER

  4. 8. Towards Anti-Virulence Antimicrobials, Discovery and Development of Sortase A Inhibitors and Investigations of Bacterial Phenotypes

    Författare :Patrick M. Wehrli; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Sortase A; SrtA; Inhibitors; Anti-virulence; Bacterial analysis; FTIR spectroscopy; Bacterial phenotyping; Design of Experiment; Multivariate Data Analysis; PCA; ToF-SIMS; Time-of-flight secondary-ion-mass-spectrometry; Lipid analysis; ppGpp; Stringent response;

    Sammanfattning : Antibiotic resistance is an emerging and serious threat to public health. Immediate actions are required to preserve current antibiotics while intensifying research efforts towards the development of new effective therapeutics. LÄS MER

  5. 9. Automated behavioral phenotyping of inbred mouse strains and mouse models of Alzheimer disease

    Författare :Alina Codita; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Behavioral characterization of various mouse strains created as models for human diseases such as Alzheimer disease requires robust phenotyping methods. Previous work on inbred mouse strains has shown that some of the widely used behavioral methods yield inconsistent results across laboratories, in spite of standardization efforts. LÄS MER

  7. 10. Developing affordable high-throughput plant phenotyping methods for breeding of cereals and tuber crops

    Författare :Fernanda Leiva; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : High-throughput plant phenotyping (HTPP) is a fast, accurate, and non-destructive process for evaluating plants' health and environmental adaptability. HTPP accelerates the identification of agronomic traits of interest, eliminates subjectivism (which is innate to humans), and facilitates the development of adapted genotypes. LÄS MER