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Visar resultat 21 - 25 av 38 avhandlingar som matchar ovanstående sökkriterier.

  1. 21. Improved oncological treatment of anal cancer

    Författare :Otilia Leon; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anal cancer; chemotherapy; Radiotherapy; Prognosis and survival; phase I II trial; Cetuximab; metastatic;

    Sammanfattning : Background: Squamous cell cancer of the anus (SCCA) is a rare malignancy, but the incidence is increasing. It isassociated with humman papilloma virus infection. The standard treatment is radiotherapy (RT) combined withchemotherapy, usually 5-fluorouracil (5FU)/Mitomycin C (MMC). LÄS MER

  3. 22. Roles of mammalian Scribble in polarity signaling, virus offense and cell-fate determination

    Författare :Michael Wigerius; Magnus Johansson; Lawrence Banks; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell polarity; scribble; tbev; RhoGTPase; jak-stat; mapk; neurite outgrowth; influenza a virus; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Mammalian Scribble is a target for proteins encoded by human papilloma virus, retro- and flaviviruses. Tick-borne encephalitis virus (TBEV) is a flavivirus that have evolved distinct strategies to escape antiviral responses. LÄS MER

  4. 23. Tonsillar cancer : incidence, prevalence of HPV and survival

    Författare :Lalle Hammarstedt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Since human papilloma virus (HPV) in the mid 1980ies was first observed in squamous cell carcinoma of the head and neck, its role and impact, especially on oral and oropharyngeal cancer, have attracted extensive interest. The aim of this thesis was to investigate if the clinical impression of increased incidence of tonsillar cancer was true, and if HPV could be linked to this increase. LÄS MER

  5. 24. Targeted Long-read Sequencing : Development and Applications in Medical Genetics

    Författare :Ida Höijer; Ulf B. Gyllensten; Adam Ameur; Lars Feuk; Winston Timp; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; long-read sequencing; targeted sequencing; targeted enrichment; CRISPR-Cas9; off-targets; medical genetics; repeat expansion; structural variant;

    Sammanfattning : Targeted sequencing has the advantage of providing pinpointed DNA information, while costs and data-analysis efforts are reduced. If targeted sequencing is combined with single molecule long-read sequencing, it can become a powerful tool to investigate genomic regions traditionally difficult using the predominantly used short-read sequencing platforms, including repetitive regions and large structural variants. LÄS MER

  7. 25. Modulation of the deubiquitinating system in viral infection, lymphoid cell activation and malignant transformation

    Författare :Ulrika Rolén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Most cellular proteins are affected by the conjugation of Ubiquitin (Ub), which may regulate their stability, activity or localization. The family of deubiquitinating enzymes (DUBs) removes Ub from conjugates and regulates the production and recycling of Ub. LÄS MER