Sökning: "jak-stat"
Visar resultat 1 - 5 av 36 avhandlingar innehållade ordet jak-stat.
1. The role of fusion oncogenes and cancer stem cells in myxoid liposarcoma
Sammanfattning : Myxoid liposarcoma (MLS) is characterised by the FUS-DDIT3, or the less common EWSR1-DDIT3 fusion oncogene and is the second most common type of liposarcoma. The fusion oncogenes encode chimeric transcription factors that are causal factors in tumourigenesis however, their functions are poorly known. LÄS MER
2. T cell Tolerance - Cellular and molecular features of immune regulation
Sammanfattning : The immune system has evolved regulatory mechanisms in order to balance the effects of deleterious immune responses. Such immunological tolerance may be specifically acquired by lymphocytes, although different cells of the immune system participate in the induction and maintenance of tolerance. LÄS MER
3. Roles of mammalian Scribble in polarity signaling, virus offense and cell-fate determination
Sammanfattning : Mammalian Scribble is a target for proteins encoded by human papilloma virus, retro- and flaviviruses. Tick-borne encephalitis virus (TBEV) is a flavivirus that have evolved distinct strategies to escape antiviral responses. LÄS MER
4. Impact of Interleukin-6 family cytokine signalling on human endothelial cells and platelets
Sammanfattning : Endothelial cells lining the luminal side of blood vessels creates a barrier between the circulating blood and the extracellular matrix. Endothelial cells have important functions in regulation of vessel tension and inflammation. LÄS MER
5. A peripheral immune response in Huntington's disease and delineation of its importance in disease pathology
Sammanfattning : Huntington’s disease (HD) is a fatal, hereditary disease for which there is no cure. It is caused by a mutation in a gene called huntingtin. HD is a so-called neurodegenerative disease, where there is a loss of neurons in areas of the brain that control body movements. This results in uncontrolled dance-like movements (chorea). LÄS MER