Sökning: "PIP5K1α"
Hittade 5 avhandlingar innehållade ordet PIP5K1α.
1. Utility of novel drug targets for treatment of metastatic cancer
Sammanfattning : Metastasis is the leading cause of cancer death because of a lack of early diagnosis tools and efficient treatment drugs. The lipid kinase phosphatidylinositol 4-phosphate 5 kinase (PIP5K1α) has been shown to play a vital role in the PI3K/AKT and KRAS signaling pathways. LÄS MER
2. The role of phosphatidylinositol 4-phosphate 5-kinase type І alpha (PIP5K1α) and utility of its inhibitor for targeting metastatic cancer
Sammanfattning : Prostate cancer (PCa) is the most common cause of cancer-related death in men after lung cancer. Annually, more than 9000 new cases are diagnosed in Sweden and 2500 of them die each year. Metastatic prostate cancer can be treated with castration. LÄS MER
3. Targeted therapeutic strategies for prostate cancer treatment using novel lipid kinase inhibitors in combination with current drugs
Sammanfattning : Prostate cancer (PCa) is one of the most common cancer types and the fifth cancer-related cause of death among Western world men. The sex steroid hormone, androgen and androgen receptor (AR) play important roles in PCa progression. LÄS MER
4. Roles of secreted bacterial factors in modulation of host cell signalling
Sammanfattning : Pathogenic bacteria employ several secretion systems to release or inject virulence factors that may alter host cell processes, generate a replicative niche, and aid bacterial survival in adverse environments. This thesis presents my investigations on how bacterial factors can modulate host cell signalling mechanisms. LÄS MER
5. Response mechanisms of normal hematopoietic cells and leukemic cells to genotoxic agents and novel therapeutic strategies
Sammanfattning : Hematopoiesis is initiated by a rare population of hematopoietic stem cells (HSC) in the bone marrow (BM). HSCs give rise to red blood cells and white blood cells of myeloid and lymphoid lineages. LÄS MER
