Sökning: "2-methoxyestradiol"

Hittade 5 avhandlingar innehållade ordet 2-methoxyestradiol.

  1. 1. Antitumor Activities of 2-Methoxyestradiol on Cervical and Endometrial Cancers In Vitro and In Vivo

    Författare :Li Li; Xin Fu; Mats Brännström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; 2-Methoxyestradiol; HeLaS3 cells; HEC-1-A cells; RL-95-2 cells; cervical cancer; endometrial cancer; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar;

    Sammanfattning : 2-Methoxyestradiol (2-ME), a metabolite of 17β-estradiol, is a potent antitumor and antiangiogenesis agent in vitro and in vivo. This study aimed to investigate the effects of 2-ME on human cervical and endometrial cancers in vitro and in vivo. LÄS MER

  3. 2. Actions of androgens and estrogens in experimental models of cardiovascular disease

    Författare :Johan Bourghardt Fagman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AR; atherosclerosis; AAA; androgens; testosterone; 2-methoxyestradiol;

    Sammanfattning : Men are at higher risk of developing both atherosclerotic cardiovascular disease and abdominal aortic aneurysm (AAA). Actions of sex steroids are hypothesized to underlie these gender differences. Testosterone, the major androgen, reduces atherosclerosis in male animal models but is suggested to promote AAA formation. LÄS MER

  4. 3. Angiostatic treatment of neuroblastoma

    Författare :Erik Wassberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Angiogensis; Angiostatic treatment; Apoptosis; Chromogranin A; Differentiation; Neuroblastoma; 2-Methoxyestradiol; 2-Propynylestradiol; TNP-470; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Neuroblastoma is a malignant solid tumor of childhood with a poor prognosis. The growth of solid tumors has been shown to be dependent on new blood vessel formation, i.e. angiogenesis. LÄS MER

  5. 4. Taking Pressure of Anaplastic Thyroid Carcinoma : Molecular Studies of Apoptosis and Interstitial Hypertension

    Författare :Pernilla Roswall; Nils-Erik Heldin; Kristofer Rubin; Sven Påhlman; Uppsala universitet; []
    Nyckelord :Medicine; Anaplastic thyroid carcinoma; Apoptosis; Cre recombinase; 2-Methoxyestradiol; Transforming growth factor-β; Transgenic mouse; Tumor-associated macrophages; Tumor interstitial fluid pressure; Medicin;

    Sammanfattning : Molecular mechanisms in the development and progression of thyroid carcinomas are still not fully understood. In the present thesis the highly malignant anaplastic thyroid carcinoma (ATC) was used to study regulation of apoptosis and tumor interstitial fluid pressure (IFP). LÄS MER

  7. 5. 2-ME-Induced Apoptotic Signalling in Prostate Cancer PC3 Cells

    Författare :Padideh Davoodpour; Marene Landström; Michael Welsh; Sten Nilsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Prostate cancer; 2-methoxyestradiol; apoptosis; shb; Smad7; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Prostate cancer is common in the Western society and current treatments are often associated with side effects, therefore improved therapeutic strategies are desired. 2-methoxyestradiol (2-ME), an endogenous metabolite of estradiol-17β inhibits tumor growth in vivo as it prevents angiogenesis. 2-ME has also direct cytotoxic effects on tumor cells. LÄS MER