Avancerad sökning

Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Epidemiology and prognosis in classical Hodgkin lymphoma

   Författare :Peter Hollander; Ingrid Glimelius; Rose-Marie Amini; Gunilla Enblad; Lydia Visser; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; rheumatoid arthritis; tumor microenvironment; immunohistochemistry; immune checkpoints; regulatory T lymphocytes; PD-1; PD-L1; Oncology; Onkologi; Patologi; Pathology;

   Sammanfattning : Classical Hodgkin lymphoma (HL) is a B cell derived neoplasm with an overall good prognosis. Its etiology and pathogenesis are largely unknown. The tumor microenvironment consists of sparse malignant cells and abundant leukocytes. LÄS MER

3. 2. Ovarian Carcinoma - Early Detection and Prognostication

   Författare :Laura Martin de la Fuente; Bröst- och ovarialcancer; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-grade serous ovarian carcinoma; early detection markers; pre-diagnostic cervical sample; copy number alterations CNA ; copy number signatures; Claudin-4; immune cell infiltration; PD-1 PD-L1 pathway;

   Sammanfattning : .... LÄS MER

4. 3. Smoking and T cell co-stimulation in rheumatoid arthritis

   Författare :Caroline Wasén; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; CD8 T cell; programmed cell death-1; programmed cell death-1 ligand 1; smoking; microRNA;

   Sammanfattning : In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. LÄS MER

5. 4. Exploring the Genetics of SLE with Linkage and Association Analysis

   Författare :Cecilia Johansson; Marta Alarcón-Riquelme; Peter Gregersen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic lupus erythematosus; complex disease; linkage analysis; association analysis; Genetik; Genetics; Genetik;

   Sammanfattning : The aim with this thesis has been to identify genes involved in the pathogenesis of Systemic Lupus Erythematosus (SLE). SLE is a systemic autoimmune disorder, most likely caused by both several genetic and environmental factors. LÄS MER

7. 5. Immunoregulatory properties of CD137-CD137 ligand axis in tumours and chronic inflammatory conditions

   Författare :Luu Nguyen Khang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : CD137 (4-1BB/TNFRSF9) is a member of the TNF receptor superfamily. CD137 expression is activation-dependent, and usually reported on T cells and NK cells. Its natural ligand is CD137 ligand (CD137L), mainly found on antigen-presenting cells (APC) such as monocytes, or dendritic cells. LÄS MER