Sökning: "PD-1 PD-L1 pathway"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden PD-1 PD-L1 pathway.
1. Epidemiology and prognosis in classical Hodgkin lymphoma
Sammanfattning : Classical Hodgkin lymphoma (HL) is a B cell derived neoplasm with an overall good prognosis. Its etiology and pathogenesis are largely unknown. The tumor microenvironment consists of sparse malignant cells and abundant leukocytes. LÄS MER
2. Ovarian Carcinoma - Early Detection and Prognostication
Sammanfattning : .... LÄS MER
3. Smoking and T cell co-stimulation in rheumatoid arthritis
Sammanfattning : In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. LÄS MER
4. Exploring the Genetics of SLE with Linkage and Association Analysis
Sammanfattning : The aim with this thesis has been to identify genes involved in the pathogenesis of Systemic Lupus Erythematosus (SLE). SLE is a systemic autoimmune disorder, most likely caused by both several genetic and environmental factors. LÄS MER
5. Immunoregulatory properties of CD137-CD137 ligand axis in tumours and chronic inflammatory conditions
Sammanfattning : CD137 (4-1BB/TNFRSF9) is a member of the TNF receptor superfamily. CD137 expression is activation-dependent, and usually reported on T cells and NK cells. Its natural ligand is CD137 ligand (CD137L), mainly found on antigen-presenting cells (APC) such as monocytes, or dendritic cells. LÄS MER