Sökning: "Nicotinic acetylcholine receptor"

Visar resultat 16 - 20 av 55 avhandlingar innehållade orden Nicotinic acetylcholine receptor.

1. 16. Neuronal nicotinic receptor subtypes in normal ageing, Alzheimer's disease and schizophrenia : influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice

   Författare :Amelia Marutle; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ageing; Alzheimer s disease; P-amyloid; Nicotinic acetylcholine receptor subtypes; Postmortem human brain; Schizophrenia; Transgenic mice;

   Sammanfattning : Neuronal nicotinic acetylcholine receptors (nAChRs) are transmitter-gated ion channel receptors which are widely distributed in the brain. They mediate the effects of several neurotransmitters including ACh, DA, 5-HT and NA and are important for many normal physiological functions in the brain and are also implicated in a number of CNS disorders, such as AD, PD, schizophrenia, Tourette's syndrome and familial epilepsy. LÄS MER

3. 17. Nicotinic transmission and drugs in anesthesia : neuromuscular blocking agents and propofol : consequences for carotid body function

   Författare :Malin Jonsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Carotid body; chemoreceptors; neuromuscular blocking agents; propofol; acetylcholine; nicotinic acetylcholine receptors;

   Sammanfattning : The carotid body is the global oxygen sensor of the human body. Acute hypoxia elicits instant hyperventilation mediated from the carotid body type 1 cells, where nicotinic transmission is a key component in oxygen sensing and signalling. LÄS MER

4. 18. Nicotinic effects on midbrain dopamine neurons : a dual mechanism of action

   Författare :Björn Schilström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :nicotine; dopamine; ventral tegmental area; glutamate; microdialysis; Fos expression; NMDA receptor; presynaptic;

   Sammanfattning : The neurons of the mesocorticolimbic dopamine system are located in the ventral tegmental area (VTA) in the mesencephalon and send their projections to forebrain structures, such as the prefrontal cortex, the amygdala and the nucleus accumbens. The dopamine system is important in regulating mood and motivation as well as cognitive function and appear to be primarily involved in drug dependence, since most drugs abused by man stimulate this system. LÄS MER

5. 19. Nicotinic mechanisms in ethanol reinforcement. A neurochemical and behavioral study

   Författare :Mia Ericson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Both smoking and alcohol consumption are known to cause severe health problems and there is an extensive co-abuse of tobacco and ethanol. The reinforcing properties of drugs of abuse may involve the brain mesolimbic dopamine system, that originates in the ventral tegmental area (VTA) and projects mainly to the nucleus accumbens. LÄS MER

7. 20. Brain glycine receptors as a common target for alcohol and the relapse-preventing drug acamprosate - a preclinical study

   Författare :Pei Pei Chau; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alcoholism; Acamprosate; Glycine receptor; Preclinical study; Dopamine; Ethanol;

   Sammanfattning : Alcohol abuse and dependence make up the most prevalent categories of substance use disorders in the world. Converging evidence from the current research group has identified two receptor populations, the glycine (GlyRs) and nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system, as two potentially important targets for the development of new medication to treat alcohol dependence. LÄS MER