Sökning: "Nicotinic acetylcholine receptor"

Visar resultat 11 - 15 av 55 avhandlingar innehållade orden Nicotinic acetylcholine receptor.

  1. 11. Theoretical Studies of Protein-Ligand Interactions

    Författare :Kuang Guanglin; Tu Yaoquan; Bulone Vincent; David van der Spoel; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Binding free energy; molecular dynamics; molecular docking; metadynamics; nicotinic receptor; amyloid fibril; PH domain; Theoretical Chemistry and Biology; Teoretisk kemi och biologi;

    Sammanfattning : The protein-ligand interaction is an important issue in rational drug design and protein function research. This thesis focuses on the study of protein-ligand interactions using various molecular modeling methods, which are used in combination to predict the binding modes and calculate the binding free energies of several important protein-ligand systems, as summarized below. LÄS MER

  3. 12. Cell membrane involving phenomena in two cholinergic systems : endocytosis in denervated striated muscle and nicotinic acetylcholine/P2-purinergic receptor interactions in mammalian inner ear

    Författare :Grace Kerali Lawoko; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : .... LÄS MER

  4. 13. Maf transcription factors in beta cell function

    Författare :Elvira Ganic; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Beta cell; MafA; type 2 diabetes; insulin secretion; transcription; monoamine oxidase; MaoA; MaoB; nicotinic receptor subunits; nAChRs;

    Sammanfattning : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. LÄS MER

  5. 14. Pamoplantar Pustulosis. Pathogenetic Studies with Special Reference to the Role of Nicotine

    Författare :Eva Hagforsen; Uppsala universitet; []
    Nyckelord :Medical sciences; Palmoplantar pustulosis; smoking; sweat gland apparatus; neuropeptides; non-neuronal cholinergic system; nicotinic receptor antibodies; autoimmune disease; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

    Sammanfattning : Palmoplantar pustulosis (PPP) is a chronic disease of unknown pathogenesis. Most of the patients were smokers. High prevalence of a number of autoimmune diseases was observed among the patients (thyroid disease 14%, gluten intolerance 8%, diabetes type 1 3%). Eosinophils and neutrophils were found in large numbers in the pustules. LÄS MER

  7. 15. Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol lowering drugs in Alzheimer's disease

    Författare :Jin Xiu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nicotinic acetylcholine receptor; Alzheimer s disease; glia cells; Abeta; cholesterol; cholesterollowering drugs;

    Sammanfattning : Nicotinic acetylcholine receptors (nAChRs) are involved in the regulation of many processes including synapses regeneration, neurotransmission and neuroprotection in the central nervous system (CNS). There is increasing evidence for the disturbances in nAChRs in Alzheimer's disease (AD). LÄS MER