Sökning: "Myeloma"

Visar resultat 16 - 20 av 104 avhandlingar innehållade ordet Myeloma.

  1. 16. Neutrophils as Suppressor Cells and their role in Multiple Myeloma

    Författare :Julia Westerlund; Myelomgruppen; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; myelom; neutrophils; T-cells; immunology; suppressor cells; myeloid-derived suppressor cells;

    Sammanfattning : .... LÄS MER

  3. 17. Identification and characterization of DNA sequence variants associated with multiple myeloma

    Författare :Mina Ali; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :Multiple myeloma; inherited susceptibility; genome-wide association study; ELL2; expression quantitative trait loci;

    Sammanfattning : Multiple myeloma (MM) is the second most common hematologic malignancy. The disease is characterized by an uncontrolled growth of malignant plasma cells in the bone marrow, producing a monoclonal immunoglobulin (“M protein”) that can be detected in peripheral blood. LÄS MER

  4. 18. Regulation of Gene Expression in Multiple Myeloma Cells and Normal Fibroblasts : Integrative Bioinformatic and Experimental Approaches

    Författare :Prasoon Agarwal; Helena Jernberg Wiklund; Håkan Axelson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; Integrative bioinformatics; Epigenetics; CGGBP1; RNA polymerase; Oncology; Onkologi; Bioinformatik; Bioinformatics;

    Sammanfattning : The work presented in this thesis applies integrative genomic and experimental approaches to investigate mechanisms involved in regulation of gene expression in the context of disease and normal cell biology.In papers I and II, we have explored the role of epigenetic regulation of gene expression in multiple myeloma (MM). LÄS MER

  5. 19. Genetic predisposition for Multiple Myeloma. Identification and functional characterization of risk variants

    Författare :Laura Duran Lozano; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; multiple myeloma; CRISPR Cas9; cancer genetics; functional characterization; Germline variants;

    Sammanfattning : Multiple myeloma (MM) is a blood malignancy originating from plasma cells. First-degree relatives of patients with MM have two- to four-fold higher risk of MM. However, the molecular basis remains largely unknown. This Ph. LÄS MER

  7. 20. Life, death ant the role of IGF-I in human multiple myeloma

    Författare :Patrik Georgii-Hemming; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Multiple Myeloma; IGF-I; apoptosis; Fas; glucocorticoids; somatostatin; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Multiple myeloma (MM) is a clonal expansion of malignant cells with a plasmablast- plasma cell morphology in the bone marrow. It is a fatal disease with a median survival of 2-3 years after start of conventional therapy. LÄS MER