Sökning: "Myeloma"

Visar resultat 21 - 25 av 104 avhandlingar innehållade ordet Myeloma.

1. 21. Infectious immunity and pneumococcal vaccine responses in multiple myeloma and related disorders

   Författare :Johanna Karlsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; multiple myeloma; Waldenstrom s macroglobulinemia; MGUS; elderly; immunity; infection; pneumococcal vaccination; ELISA; opsonophagocytosis;

   Sammanfattning : Multiple myeloma (MM), Waldenstrom’s macroglobulinemia (WM), and monoclonal gammopathy of undetermined significance (MGUS) are B cell conditions associated with suppressed immune functions and susceptibility to infection. Severe pneumococcal disease is common not least in MM patients and vaccination is considered important, although the protective efficacy is debated. LÄS MER

3. 22. The Regulation of Growth and Survival in Human Multiple Myeloma Cells by IGF-I Receptor Signaling

   Författare :Thomas Strömberg; Helena Jernberg Wiklund; Kenneth Nilsson; Anders Waage; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Multiple myeloma; IGF-IR; apoptosis; somatostatin; octreotide; dexamethasone; GSK-3; mTOR; rapamycin; RTK inhibitor; Patologi; Pathology; Patologi;

   Sammanfattning : Multiple myeloma (MM) is an incurable B-cell malignancy mainly localized to the bone marrow. Our aim was to examine the growth- and survival-promoting role of the IGF-IR and its downstream signaling components in MM cells to identify potential targets for therapy. LÄS MER

4. 23. Novel Superantigens for Immunotherapy of Multiple Myeloma

   Författare :Lotten Ragnarsson; Uppsala universitet; []
   Nyckelord :;

   Sammanfattning : .... LÄS MER

5. 24. Therapeutic potential of natural killer cells in multiple myeloma

   Författare :Evren Alici; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Natural Killer cells; immunotherapy; multiple myeloma; gene therapy;

   Sammanfattning : Multiple Myeloma (MM) is an incurable plasma cell neoplasm with a median length of survival after diagnosis of approximately three years; therefore new treatment modalities to eradicate the disease are needed. Although the disease remains incurable, current main alternatives are drug treatment modalities and autologous stem cell transplantation (ASCT). LÄS MER

7. 25. Natural and induced idiotype immunity in patients with multiple myeloma

   Författare :Lotta Hansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Myeloma; idiotype; vaccination; GM-CSF; IL-12; clonal B cells; T cell epitopes; signal transduction molecules; activation markers;

   Sammanfattning : There is a great need for development of new treatment alternatives for patients with multiple myeloma (MM). The idiotype (Id) immunoglobulin (Ig) expressed by the myeloma B cell clone might be regarded as a tumor specific antigen and as such a target for immunotherapy. LÄS MER