Sökning: "inherited susceptibility"

Visar resultat 1 - 5 av 45 avhandlingar innehållade orden inherited susceptibility.

  1. 1. Neurotoxic Effects of Nicotine During Neonatal Brain Development : Critical Period and Adult Susceptibility

    Författare :Emma Ankarberg; Per Eriksson; Richard F. Seegal; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; nicotine; neonatal development; behaviour; nicotinic receptors; susceptibility; cholinergic system; paraoxon; PBDE; Biologi; Biology; Biologi;

    Sammanfattning : This thesis examined neurotoxic effects of nicotine exposure during a defined critical period of neonatal brain development in mice.In our environment there are numerous hazardous contaminants that an individual can be exposed to during its entire lifetime. LÄS MER

  3. 2. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

    Författare :Michael Jewett; Translationell Neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

    Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. LÄS MER

  4. 3. Genetic susceptibility to cervical and gastric cancer

    Författare :Patrik Magnusson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical cancer; gastric cancer; genetic susceptibility; familiality; heritability; HPV; Helicobacter pylori; genetic association; HLA; P53; loss of heterozygosity; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Cervical and gastric cancer both to a large extent depend on infectious agents. Cervical infection with human papilloma virus increases the risk for cervical cancer substantially, and infection with the bacteria Helicobacter pylori increases the risk for gastric cancer. LÄS MER

  5. 4. Identification and characterization of DNA sequence variants associated with multiple myeloma

    Författare :Mina Ali; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :Multiple myeloma; inherited susceptibility; genome-wide association study; ELL2; expression quantitative trait loci;

    Sammanfattning : Multiple myeloma (MM) is the second most common hematologic malignancy. The disease is characterized by an uncontrolled growth of malignant plasma cells in the bone marrow, producing a monoclonal immunoglobulin (“M protein”) that can be detected in peripheral blood. LÄS MER

  7. 5. Modeling genetic susceptibility to multiple sclerosis

    Författare :Helga Westerlind; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main aim of this thesis was to investigate genetic and environmental factors and their role in the etiology of Multiple Sclerosis (MS) by using comprehensive registry data or novel computationally intense methods. To date, over 100 genes associated with MS have been identified, but how they interact in the risk for the disease is not yet fully understood. LÄS MER