Sökning: "Fas"

Visar resultat 1 - 5 av 332 avhandlingar innehållade ordet Fas.

  1. 1. Regulation of apoptosis in human multiple myeloma

    Författare :Helena Spets; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; apoptosis; multiple myeloma; IL-6; Bcl-2; Fas; dexamethasone; IGF-I; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Multiple myeloma (MM) is a clonal expansion of malignant plasmablasts-plasma cells in the bone marrow. MM is slowly proliferating and an increased resistance to apoptosis may be crucial for the tumor progression. LÄS MER

  3. 2. Life, death ant the role of IGF-I in human multiple myeloma

    Författare :Patrik Georgii-Hemming; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Multiple Myeloma; IGF-I; apoptosis; Fas; glucocorticoids; somatostatin; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Multiple myeloma (MM) is a clonal expansion of malignant cells with a plasmablast- plasma cell morphology in the bone marrow. It is a fatal disease with a median survival of 2-3 years after start of conventional therapy. LÄS MER

  4. 3. Identifying Risk Genes for Cervical Cancer : Using Affected Sib-Pairs and Case-Control Materials from Sweden

    Författare :Malin Engelmark; Ulf Gyllensten; Dan Holmberg; Uppsala universitet; []
    Nyckelord :Medicine; Cervical cancer; HPV; Affected sib-pairs; HLA; Fas; Genomewide scan; 9q32; TSCOT; Medicin;

    Sammanfattning : Cervical cancer is a multifactorial disease. Infection by oncogenic types of the human papillomavirus (HPV) is the major environmental risk factor and host genetic susceptibility also influences disease development. The aim of this thesis is to identify and analyse risk genes involved in the genetic predisposition to cervical carcinoma. LÄS MER

  5. 4. Tumor biological aspects of the mucin-like glycoprotein CD43

    Författare :Sirle Laos; Göteborgs universitet; []
    Nyckelord :CD43; leukosialin; sialophorin; mucin; colon adenoma; proteolytic processing; ; NF-kappaB; p65; chemokine; p53; ARF; Fas; apoptosis; transformation;

    Sammanfattning : Cancer cells overexpress aberrant forms and amounts of mucins, which contribute to tumor development by regulating cell growth, survival, adhesion, invasion and immune responses. CD43, a type I transmembrane protein, is a mucin-like molecule expressed under normal physiological conditions by most hematopoietic cell types. LÄS MER

  7. 5. Carbide and MAX-Phase Engineering by Thin Film Synthesis

    Författare :Jens-Petter Palmquist; Ulf Jansson; M. Jochen Schneider; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; Thin films; microstructure; epitaxy; carbide; WC; MAX-phase; Ti3SiC2; DC magnetron sputtering; PVD; Reciprocal Space Mapping; RSM; Oorganisk kemi; Inorganic chemistry; Oorganisk kemi;

    Sammanfattning : This thesis reports on the development of low-temperature processes for transition metal carbide and MAX-phase thin film growth. Magnetron sputtering and evaporation, far from thermodynamical equilibrium, have been utilised to engineer the properties of the films by physical and chemical control. LÄS MER