Sökning: "Multidrug-resistance"

Visar resultat 16 - 20 av 57 avhandlingar innehållade ordet Multidrug-resistance.

  1. 16. Heterogeneity of leukemic cells with regard to daunorubicin accumulation and efflux : potential role in drug resistance

    Författare :Eva Knaust; Linköpings universitet; []
    Nyckelord :Drug resi stance. acute myeloid leukemia; flow cytometry; gene expression; transport kinetics; apoptosis; MEDICINE; MEDICIN;

    Sammanfattning : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myelocytic leukemia (AML) and other malignancies. Drug resistance is multifactorial; the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (PPG), a transmembrane transport protein with a pump function, encoded by the mdr 1 gene. LÄS MER

  3. 17. Antibiotic Resistance : Selection in the Presence of Metals and Antimicrobials

    Författare :Lisa M. Albrecht; Dan I Andersson; Alex O'Neill; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; Metals; Antimicrobials; Bacterial evolution; Bacterial genetics; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : The external environment is complex: Antibiotics, metals and antimicrobials do not exist in isolation but in mixtures. Human activities such as animal husbandry, fertilization of agricultural fields and human medicine release high amounts these compounds into the environment. LÄS MER

  4. 18. Molecular basis for the mechanism of action and resistance to artemisinin combination therapy in Plasmodium falciparum

    Författare :Pedro Ferreira; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasmodium falciparum;

    Sammanfattning : Malaria, caused by the Plasmodium falciparum parasite, remains a leading cause of death among children in Africa. To improve treatment efficacy and delay development and spread of antimalarial drug resistance artemisinin artemisinin-based combination therapy (ACT) is now globally recommended as first-line treatment of uncomplicated P. LÄS MER

  5. 19. Staphylococcal prosthetic joint infections : similar, but still different

    Författare :Staffan Tevell; Bo Söderquist; Åsa Nilsdotter-Augustinsson; Annelies Zinkernagel; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prosthetic joint infections; staphylococcal infections; nasal carriage; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus capitis; NRCS-A; antibiotic resistance; heterogeneous glycopeptide resistance; whole-genome sequencing; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Staphylococci constitute a major part of our commensal flora but are also the most common bacteria causing prosthetic joint infections (PJIs), a dreaded complication of arthroplasty surgery. However, not all staphylococci are the same. LÄS MER

  7. 20. Protein Structure and Interaction in Health and Disease

    Författare :Cecilia Andrésen; Maria Sunnerhagen; Patrik Lundström; Lena Mäler; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : This thesis focuses on protein structure, dynamics and interaction and their relation to human disease. In particular, the biophysical and structural properties of both well-ordered and partially disordered proteins are studied using a range of biophysical techniques such as circular dichroism spectroscopy, fluorescence spectroscopy, mass spectrometry and nuclear magnetic resonance spectroscopy. LÄS MER