Sökning: "Maria Sunnerhagen"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Maria Sunnerhagen.

  1. 1. Structural insights into protein-protein interactions governing regulation in transcription initiation and ubiquitination

    Författare :Madhanagopal Anandapadamanaban; Maria Sunnerhagen; Martin Moche; Marie Wahren-Herlenius; Cynthia Wolberger; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Virtually every aspect of the cellular processes in eukaryotes requires that the interactions between protein molecules are well coordinated in different regulatory pathways. Any protein dysfunction involved in these regulatory pathways might lead to various pathological conditions. LÄS MER

  3. 2. Protein Structure and Interaction in Health and Disease

    Författare :Cecilia Andrésen; Maria Sunnerhagen; Patrik Lundström; Lena Mäler; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : This thesis focuses on protein structure, dynamics and interaction and their relation to human disease. In particular, the biophysical and structural properties of both well-ordered and partially disordered proteins are studied using a range of biophysical techniques such as circular dichroism spectroscopy, fluorescence spectroscopy, mass spectrometry and nuclear magnetic resonance spectroscopy. LÄS MER

  4. 3. MYC and MexR interactions with DNA : a Small Angle Scattering perspective

    Författare :Francesca Caporaletti; Maria Sunnerhagen; Björn Wallner; Anne Martel; Ann Terry; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Protein-DNA complexes govern transcription, that is, the cellular mechanism that converts the information stored in the DNA into proteins. These complexes need to be highly dynamic to respond to external factors that regulate their functions in agreement with what the cells need at that time. LÄS MER

  5. 4. Structural biology of transcriptional regulation in the c-Myc network

    Författare :Sara Helander; Maria Sunnerhagen; Patrik Lundström; Lila M. Gierasch; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : The oncogene c-­‐Myc is overexpressed in many types of human cancers and regulation of c-­‐Myc expression is crucial in a normal cell. The intrinsically disordered N-­‐terminal transactivation domain interacts with a wide range of proteins regulating c-­‐Myc activity. LÄS MER

  7. 5. Structure-function studies on TRIM21/Ro52, a protein involved in autoimmune diseases

    Författare :Janosch Hennig; Maria Sunnerhagen; Kylie J. Walters; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi;

    Sammanfattning : Several members of the tripartite motif (TRIM) protein family are involvedin antiviral activity and immunity and have been linked to severaldiseases. TRIM21, the main object of this thesis, is involved in Sjögrensyndrome (SS) and systemic lupus erythematosus (SLE), where patientsoften have autoantibodies against different epitopes on TRIM21. LÄS MER