Sökning: "Multidrug-resistance"

Visar resultat 21 - 25 av 57 avhandlingar innehållade ordet Multidrug-resistance.

  1. 21. Acute myeloid leukemia : apoptotic signalling and gene expression associated with treatment response

    Författare :Marita Lagergren Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukemia (AML) is a severe, life threatening malignancy characterized by a clonal expansion of immature myeloid cells in the bone marrow, resulting in severe infections and bleedings. High dose chemotherapy is able to normalize the blood and bone marrow morphology (complete remission, CR) in a majority of treated patients, but recurrent disease, typically occurs within 1-2 years. LÄS MER

  3. 22. Cadmium in the mammary gland and neonatal intestine : transport pathways and interactions with calcium and iron

    Författare :Helena Öhrvik; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Cadmium is a ubiquitous toxic metal known to cause several adverse health effects in humans. Newborns have an increased gastrointestinal absorption of cadmium compared to adults and seem to be more sensitive to cadmium toxicity. LÄS MER

  4. 23. Adrenocortical tumors : Diagnosis, growth regulation and treatment

    Författare :Carin Backlin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Monoclonal antibodies generated by immunization with human adrenocortical cells reacted with the normal adrenal cortex, adrenocortical adenomas and carcinomas, but failed to stain a variety of normal tissues, renal cell carcinoma, and pheocromocytomas. The antibodies can be used to improve histological diagnosis and characterization of human adrenal lesions, and possibly for scintigraphic detection. LÄS MER

  5. 24. Exposure to xenobiotic chemicals disrupts metabolism, rhythmicity and cell proliferation in Drosophila melanogaster

    Författare :Hao Cao; Helgi B. Schiöth; Michael J. Williams; Jan Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; xenobiotics; metabolism; insulin signalling; circadian rhythm; carcinogen; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap;

    Sammanfattning : Most species are constantly exposed to xenobiotic chemicals through multiple routes. Among all categories of xenobiotics, phthalates and bisphenols are two of the most widely used plasticizers and can be found in polyvinyl chloride (PVC) materials, medical devices and even drinking water. LÄS MER

  7. 25. Optimization of Colistin Dosage in the Treatment of Multiresistant Gram-negative Infections

    Författare :Matti Karvanen; Otto Cars; Lena E Friberg; Vincent H Tam; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colistin; CMS; Pharmacology; Pharmacokinetics; PKPD; Antibiotics; Combination therapy; Pharmacometrics; Dosing regimens; Antibiotic resistance; Infectious Diseases; Infektionssjukdomar;

    Sammanfattning : As multidrug resistance in Gram-negative bacilli increases, the old antibiotic colistin has rapidly gained attention as one of few last line treatment options in the form of colistin methanesulfonate (CMS), which is hydrolyzed to colistin both in vitro and in vivo. There is a dearth of knowledge on fundamental aspects of colistin, including pharmacokinetics and optimal dosing regimens. LÄS MER